By Jeffrey M. Jacobson
In Immunotherapy for Infectious disorder, Jeffrey M. Jacobson, MD, and a panel of top researchers evaluate the state of the art for treating quite a few infections-particularly HIV-by manipulating the immune system's reaction instead of via chemical medications. The individuals synthesize the foundations of immune safeguard at the molecular point (monoclonal antibodies, vaccines, equipment of antigen presentation, and cytokines and cytokine antagonists), in addition to at the mobile and medical degrees degrees as a security opposed to an infection. The evaluation of the present nation of anti-HIV immunotherapy covers HIV-specific passive and energetic immunization recommendations, gene treatment, and host cell-targeted ways for treating HIV an infection and restoring immune functionality.
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Extra info for Immunotherapy for Infectious Disease, 1st edition
Sample text
Pat Bucy and Paul Goepfert INTRODUCTION In this chapter some of the functional implications of our current understanding of the basic physiology of T-cell mediated immune function for problems in infectious disease are discussed. The subtleties of the process of T-cell antigen “recognition” and the heterogeneity of kinds of functional responses within the T-cell system are a major focus. Finally, some features of the anatomic compartmentalization of the immune system and how limited access to tissue compartments skews our thinking about in vivo immunity in humans are explored.
In this context, the term anergy simply indicates that absence of the particular function is used as the index of response, not physical absence (clonal deletion) of the relevant cells. In some circumstances, immune deviation to produce Th2-like cytokines in contrast to the Th1 pattern somewhat accounts for such unresponsiveness. Examples include lepromatous leprosy (60,73,74) and the well-studied Leishmania major infection in mice (65–75). In the case of HIV-1 infection, although such classical immune deviation has been suggested (76), an alternative possibility is that direct interaction of viral particles with the CD4 molecule together with persistent low concentrations of antigens yields T-cells with low-level TCR stimulation that fail to respond with high IL-2 production.
Descriptive imprinting in the immune response against HIV1. Immunol Today. 1994; 13:475–478. 59. Nara PL, Garrity R. Deceptive imprinting: a cosmopolitan strategy for complicating vaccination. Vaccine 1998; 16:1780–1787. 2 Some Basic Cellular Immunology Principles Applied to the Pathogenesis of Infectious Diseases R. Pat Bucy and Paul Goepfert INTRODUCTION In this chapter some of the functional implications of our current understanding of the basic physiology of T-cell mediated immune function for problems in infectious disease are discussed.