By M. D. Mashkovsky, L. N. Yakhontov (auth.), Dr. Ernst Jucker (eds.)
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Extra resources for Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques
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Med. [Bulletin of Experimental Biology and Medicine], No. ). Developments in chemistry and pharmacology of synthetic quinuclidines 80 81 61 E. A. Baumanis, V. Z. Gorkin, I. E. Kalinina, M. E. Kaminka, and M. D. Mashkovsky: Farmakol. Toksikol. ). H. M. G. Untch: J. Med. Chem. 23, 180 (1980). 82 M. Schachter: Int. Encyclopedia Pharmacol. , sect. 74: Histamine and Antihistamines. Pergamon Press, Oxford, New York 1973. 83 R. Tonder and U. Urbain: Chem. 19, 207 (1966). 84 L. Cook and E. Weidley: Ann.
M. Krasnokutskaya, AS. A. N. YakhontOY: Khim. Geterotsikl. Soyed. ). J. A Wefar: J. Med. Chern. 18, 666 (1975). British Pat. 1,490,659 French Pat. 2,262,985 Swiss Pat. 608,015, US Pat. 4,117139 and 4,038,402. E. Ya. E. V. M. D. N. ). P. Firsova, AV. M. E. Ya. D. N. Yakhontov: Zh. Org. Khim. ). A V. Krasniansky, N. D. Kremliakova, S. M. Svetlikin, Yu. N. Smirsky, AP. Ya. E. N. ). E. Kaminka: Farmakol. Toksikol. ). E. P. D. Farm. Zh. ). E. Kaminka: Farmakol. Toksikol. ). I. V. Golovanova and S.
Resistance by dermatophytes is apparently no problem. The drug is used orally to treat dermatophyte infections (dermatomycoses, onychomycoses, tinea capitis), and is relatively welltolerated. Its main drawback from the clinical point of view is its narrow spectrum of activity. 3 Tolnaftate Tolnaftate (III) is a synthetic drug used for the topical treatment of dermatophytoses and pityriasis versicolor. It has a fungicidal effect on dermatophytes although this activity has only been demonstrated in growing cells [6].