By Birgit Weyand, Massimo Dominici, Ralf Hass, Roland Jacobs, Cornelia Kasper
Engineered MSCs from Patient-Specific iPS Cells, by way of Irina Eberle, Mohsen Moslem, Reinhard Henschler, Tobias Cantz
Fate of Intravenously Injected Mesenchymal Stem Cells and value for scientific program, via Beate Wagner, Reinhard Henschler
The Implications of Stem phone functions for ailments of the respiration procedure, via Mei Ling Lim, Philipp Jungebluth, Paolo Macchiarini
Potential of Mesenchymal Stem cellphone purposes in Plastic and Reconstructive surgical procedure, through Birgit Weyand, Peter M. Vogt
General ideas for the Regeneration of Bone and Cartilage, by way of Michael Jagodzinski, C. Haasper
Adult Mesenchymal Stem Cells Explored within the Dental box, through ok. M. Fawzy El-Sayed, C. Dörfer, F. Fändrich, F. Gieseler, M. H. Moustafa, H. Ungefroren
Mesenchymal Stem mobilephone remedy and Lung illnesses, via Khondoker M. Akram, Sohel Samad, Monica Spiteri, Nicholas R. Forsyth
Mesenchymal Stem Cells as mobile Immunotherapeutics in Allogeneic Hematopoietic Stem mobile Transplantation, via Claudia Papewalis, Daniela Topolar, Barbara Götz, Stefan Schönberger, Dagmar Dilloo
New Cell-Based remedy Paradigm: Induction of Bone Marrow-Derived Multipotent Mesenchymal Stromal Cells into Pro-Inflammatory MSC1 and anti inflammatory MSC2 Phenotypes, through Aline M. Betancourt
Interactions among Mesenchymal Stem Cells and Dendritic Cells, by means of Grazia Maria Spaggiari, Lorenzo Moretta
MSC and Tumors: Homing, Differentiation, and Secretion impression healing power, via Naomi D’souza, Jorge Sans Burns, Giulia Grisendi, Olivia Candini, Elena Veronesi, Serena Piccinno, Edwin M. Horwitz, Paolo Paolucci, Pierfranco Conte, Massimo Dominici
Sources of Mesenchymal Stem Cells: present and destiny medical Use, by means of Michela Pozzobon, Martina Piccoli, Paolo De Coppi
Role of the ecu Framework in law of Stem Cell-Based items, by means of Giovanni Migliaccio, Cristina Pintus
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Extra resources for Mesenchymal Stem Cells - Basics and Clinical Application II
Sample text
V. injected MSCs and monocytes/macrophages [71]. Recent work by Akiyama et al. [2] has elucidated a role for fas ligand expressed on MSCs, by transiently inducing apoptosis in T cells. It has been shown to involve the secretion of MCP-1 by MSCs, which recruits T cells to apoptosis. The apoptosing T cells activate macrophages to produce TGF-beta, increasing regulatory T cells and thus promoting immune tolerance. More or less direct actions of MSCs on immune cells also involve the secretion of anti-inflammatory protein TSG-6 by activated MSCs which in a zymosan-induced mouse peritonitis model decreased TLR2/NF-jB signaling in resident macrophages [16].
Mol Biol Cell 18:2873–2882 Karp JM, Leng Teo GS (2009) Mesenchymal stem cell homing: the devil is in the details. Cell Stem Cell 4:206–216 Kidd S, Spaeth E, Watson K, Burks J, Lu H, Klopp A, Andreeff M, Marini FC (2012) Origins of the tumor microenvironment: quantitative assessment of adipose-derived and bone marrow-derived stroma. PLoS One 7(2):e30563 (Epub 2012 Feb 20) Kim J, Hematti P (2009) Mesenchymal stem cell-educated macrophages: a novel type of alternatively activated macrophages. Exp Hematol 37:1445–1453 Koç ON, Gerson SL, Cooper BW, Dyhouse SM, Haynesworth SE, Caplan AI, Lazarus HM (2000) Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture- expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy.
Still, these data argue in favor of locally acting, homed MSCs in a part of the investigated pathologies. Fate of Intravenously Injected Mesenchymal Stem Cells 29 11 Influence of Local Irradiation on the Fate of Intravenously Transplanted MSCs Francois et al. , on abdomen or legs) affected the distribution of hMSCs after IV infusion in NOD/SCID mice as compared to untreated animals. Without irradiation, intravenously infused hMSCs were found only in minimal amounts exclusively in the lung, bone marrow, and muscles.