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Extra resources for Emerging Infectious Diseases - Vol. 14, No.7, July 2008

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Moreover, different rates of occurrence in these temporally divergent populations suggest that toxinotype V may be an increasing cause of human CDAD, relative to other strains. The toxinotype V animal isolates included in our study have been previously identified as PCR ribotype 078, the most prevalent ribotype among calves and pigs, accounting for 94% (bovine) and 83% (swine) of isolates tested from multiple geographic regions (8). Food animal isolates we tested shared a high degree of similarity with human isolates, with 2 instances of animal–human isolate pairs appearing indistinguishable by REA or PFGE subtyping.

Gov/eid • Vol. 14, No. 7, July 2008 Alcaligenes xylosoxidans Bloodstream Infections cultures reported from both laboratories) were associated with a single outpatient oncology office, Office B. The other 3 hospitals reported that they had not identified any A. xylosoxidans bloodstream infections in the past 3 months. To identify the source of the outbreak and risk factors for infection and to implement control measures, ACDC then initiated an outbreak investigation. Methods The outbreak investigation focused on Office B.

Our investigation has limitations. We did not culture A. xylosoxidans from the multidose vials. The original vials, used when the outbreak began, had already been discarded and were not available for testing by the time we were notified in January 2002. gov/eid • Vol. 14, No. 7, July 2008 Alcaligenes xylosoxidans Bloodstream Infections nursing staff accessed the CVCs. Although the contamination of multidose vials remains suggestive, we suspect that they were the most likely source.

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