By Werner Zimmerli M.D., Andrej Trampuz (auth.), T. Fintan Moriarty, Sebastian A.J. Zaat, Henk J. Busscher (eds.)
Biomaterials linked an infection (BAI) is without doubt one of the most typical issues linked to implantation of any biomaterial despite shape or functionality. those infections often contain bacterial colonization and biofilm formation at the biomaterial itself, rendering the an infection impervious to antimicrobials and host defenses. moreover, it truly is changing into more and more transparent that an infection of the encompassing tissues additionally performs a huge function in BAI, and that the an infection might be prompted through the composition and layout of the implanted biomaterial. during this booklet, around the globe leaders within the box deal with this serious challenge within the translation of biomaterials examine into medical perform. The e-book starts with an emphasis at the newest examine within the pathogenesis of BAI from microbiological, immunological, and fabrics technology views. the present state-of-the-art in antimicrobial activation of biomaterials via floor amendment and the incorporation of antimicrobial brokers is then mentioned. within the concluding chapters, profitable translation of a range of antimicrobial applied sciences from preclinical examine into scientific use is defined along a dialogue of the application of those units and views for destiny improvement. This booklet is vital interpreting for researchers and clinicians who're attracted to figuring out the basics of BAI, the newest in antimicrobial fabrics study, and the state-of-the-art in clinically to be had antimicrobial containing clinical units.
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Additional resources for Biomaterials Associated Infection: Immunological Aspects and Antimicrobial Strategies
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J Bone Joint Surg Am. 2012 (in revision). 87. Berbari E, Mabry T, Tsaras G, et al. Inflammatory blood laboratory levels as markers of prosthetic joint infection: a systematic review and meta-analysis. J Bone Joint Surg Am. 2010;92:2102–9. 88. Piper KE, Fernandez-Sampedro M, Steckelberg KE, et al. C-reactive protein, erythrocyte sedimentation rate and orthopedic implant infection. PLoS One. 2010;5:e9358. 89. Tigges S, Stiles RG, Roberson JR. Appearance of septic hip prostheses on plain radiographs.
Sendi P, Christensson B, Uckay I, et al. Group B streptococcus in prosthetic hip and knee joint-associated infections. J Hosp Infect. 2011;79:64–9. 106. Sendi P, Rohrbach M, Graber P, et al. Staphylococcus aureus small colony variants in prosthetic joint infection. Clin Infect Dis. 2006;43:961–7. 107. Stengel D, Bauwens K, Sehouli J, et al. Systematic review and meta-analysis of antibiotic therapy for bone and joint infections. Lancet Infect Dis. 2001;1:175–88. 108. Zimmerli W, Frei R, Widmer AF, et al.
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