By Prof. Dr. med. H. A. Tritthart (auth.), Prof. Dr. F. Bender, Prof. Dr. W. Meesmann (eds.)

Calcium antagonists are at present the main generally investigated medications for the therapy of middle illness. they're used around the world with nice luck and a relatively low occurrence of difficult reactions. the main favourite and perilous ailments in modem industrialized societies - a number of the varieties and problems of coronary arteriosclerosis and arterial high blood pressure - are amenable to therapy with calcium antagonists. The pharmacological spectrum of calcium antagonists is very particular and used to be supplemen­ ted many years in the past by means of gallopamil, a verapamil analogue. The experimental paintings suggested at this symposium used to be fascinated about results of gallopamil at the electrophysiology of the guts, relatively in acute myocardial ischemia. New healing positive factors of myocardial hypertrophy and hypertrophic cardiomyopathy are mentioned. In scientific perform, gallopa­ mil has proved fairly precious for the therapy of angina pectoris. stories evaluating gallopamil with different calcium antagonists are defined to profile the houses of the medication when it comes to their particular healing worth. there's nonetheless a necessity for extra differential healing trials. this primary foreign symposium on gallopamil used to be attended by means of specialists from associations dedicated to theoretical and scientific learn and basic practice.

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Extra resources for Treatment with Gallopamil: Results of recent research on calcium antagonism

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Thandroyen F, Higginson L, Opie L (1982) Protective effect of a calcium channel antagonist agent (CCAA), tiapamil (Ro-1l-1781) against ventricular fibrillation during acute myocardial ischemia and reperfusion. Circulation 66 (Suppl II):140 37. Raeder EA, Verrier RL, Lown B (1986) Protective effect of tiapamil against ventricular fibrillation during coronary artery occlusion. Am Heart J 111:878-882 38. Fagbemi 0, Parratt JR (1981) Calcium antagonists prevent early postinfarction ventricular fibrillation.

Ernst Hamorheologisches Forschungslabor Klinik fUr physikalische Medizin Universitat Miinchen ZiemssenstraBe 1 D-8000 Munich 2 West Germany 28 Effect of gallopamil on local excitability, conduction and the index of arrhythmogenicity in the early phase of acute myocardial ischaemia M. Budden, W. Meesmann Department of Pathophysiology, Clinical Centre of the University (GHS) of Essen During the first 30 minutes of acute LAD occlusion, ventricular arrhythmias and ventricular fibrillation occur with bimodal distribution.

Unlike nifedipine, gallopamil also significantly reduced delayed reperfusion arrhythmias. The differences in the anti-arrhythmic and antifibrillatory effects of gallopamil and nifedipine during acute myocardial ischaemia and after reperfusion can be explained by differences in their bioelectrical pharmacological properties and in the degree of cardioprotection. References 1. Goldstein S, Lanids JR, Leighton R (1981) Characteristics of the resuscitated out-of-hospital cardiac arrest victims with coronary heart disease.

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