By Panayotis G. Katsoyannis (auth.), P. G. Katsoyannis (eds.)
Leonidas Zervas, Emeritus Professor of natural chemistry on the college of Athens, and earlier president of the nationwide Academy of Greece, cele brated his 70th birthday this prior yr. for nearly fifty years Zervas dedicated his clinical abilities and conception to the development of chemistry, really within the box of peptides and proteins. certainly, his efforts, besides these of his instructor, co-worker, and buddy, Max Bergmann, laid the rules for a brand new period within the chemistry of peptides and proteins. a lot of his colleagues and previous scholars felt that it'd be so much at the present to honor him with a commemorative quantity. They acceptable have contributed to this quantity chapters describing a few of their paintings and reviewing the developments specifically parts of polypeptide chemistry. They devote this quantity to Leonidas Zervas as an expression in their esteem and appreciation for the position he has performed for the previous half-century within the box of peptides and proteins.
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Extra resources for The Chemistry of Polypeptides: Essays in Honor of Dr. Leonidas Zervas
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1955, Ober aktivierte Ester. V. Verwendung der Cyanmethylester-Methode zur Herstellung von (N-Carbobenzoxy-S-benzyl-L-cysteinyl)L-tyrosyl-L-isoleucin auf verschiedenen Wegen, Helv. Chim. Acta 38: 1508. Jakubke, H. D .. 1965a. Darstellung N-geschtitzter Aminosiiureester des 8-Hydroxychinolins und deren Verwendung als reaktive Zwischenprodukte fUr die Peptidsynthese, Z. Naturforsch. 20b: 273. Jakubke, H. D .. 1965b. Ober aktivierte Ester; Peptidsynthese mit N-Acylaminosiiure-8thiochinolyl Estern.
1969). In principle, only the e-amino group of lysine and -SH groups of cysteine residues need to be protected. The difficulties encountered in the purification of longer chains carrying numerous protecting groups suggest that, in the synthesis oflarge molecules, minimal protection is to be preferred, and hence further application of active esters, both in solution and in SPPS, can be expected in the future. REFERENCES Anderson, G. W .. Zimmerman, J. , and Callahan, F. , 1963, N-Hydroxysuccinimide esters in peptide synthesis, J.