By Sherwood Hall
content material: Pharmacology of marine pollution : results on membrane channels / Gary Strichartz and Neil citadel --
Biosynthesis of purple tide pollutants / Yuzuru Shimizu, Sandeep Gupta, and Hong-Nong Chou --
The saxitoxins : assets, chemistry, and pharmacology / Sherwood corridor, Gary Strichartz, E. Moczydlowski, A. Ravindran, and P.B. Reichardt --
High-performance liquid chromatographic process utilized to paralytic shellfish poisoning study / John J. Sullivan --
A bacterial resource of tetrodotoxins and saxitoxins / Mark L. Tamplin --
normal pollutants from cyanobacteria (blue-green algae) / Wayne W. Carmichael, Nik A. Mahmood, and Edward G. Hyde --
Nicotinic acetylcholine receptor functionality studied with man made (+)-anatoxin-a and derivatives / K.L. Swanson, H. Rapoport, R.S. Aronstam, and E.X. Albuquerque --
Polyether pollutants concerned with seafood poisoning / Takeshi Yasumoto and Michio Murata --
Ca-dependent excitatory results of maitotoxin on tender and cardiac muscle / Yasushi Ohizumi and Masaki Kobayashi --
X-ray crystallographic reports of marine pollutants / Gregory D. Van Duyne --
Brevetoxins : distinctive activators of voltage-sensitive sodium channels / Vera L. coach, Richard A. Edwards, Alina M. Szmant, Adam M. Stuart, Thomas J. Mende, and Daniel G. Baden --
Detection, metabolism, and pathophysiology of brevetoxins / Mark A. Poli, Charles B. Templeton, Judith G. velocity, and Harry B. Hines --
The molecular foundation of ciguatoxin motion / Christian Frelin, Monique Durand-Clément, Jean-Noël Bidard, and Michel Lazdunski --
A viewpoint on palytoxin / Gary Strichartz --
Mechanism of palytoxin motion at the epidermal progress issue receptor / Elizabeth V. Wattenberg, Hirota Fujiki, and Marsha wealthy Rosner --
Mechanism of pharmacological motion of palytoxin / Yasushi Ohizumi --
construction of antibodies and improvement of a radioimmunoassay for palytoxin / Lawrence Levine, Hirota Fujiki, Hilda B. Gjika, and Helen Van Vunakis --
New tumor promoters from marine usual items / Hirota Fujiki, Masami Suganuma, Hiroko Suguri, Shigeru Yoshizawa, Kanji Takagi, Michie Nakayasu, Makoto Ojika, Kiyoyuki Yamada, Takeshi Yasumoto, Richard E. Moore, and Takashi Sugimura --
Pharmacological and toxicological stories of palytoxin / James A. Vick and Joseph Wiles --
Conotoxins : distinctive peptide ligands from snail venoms / Baldomero M. Olivera, David R. Hillyard, Jean Rivier, Scott Woodward, William R. grey, Gloria Corpuz, and Lourdes J. Cruz --
Sea anemone polypeptide pollutants affecting sodium channels : preliminary structure-activity investigations / William R. Kem, Michael W. Pennington, and Ben M. Dunn --
resolution constitution of sea anemone pollutants via NMR spectroscopy / N. Vasant Kumar, Joseph H.B. Pease, Hugues Schweitz, and David E. Wemmer --
Cytolytic peptides of sea anemones / Alan W. Bernheimer --
pollutants from marine invertebrates / M.J.A. Walker and V.L. Masuda --
a few normal jellyfish pollutants / Joseph W. Burnett --
Neurotoxins from sea snake and different vertebrate venoms / Anthony T. Tu --
foundation, chemistry, and mechanisms of motion of a repellent, presynaptic excitatory, ionophore polypeptide / P. Lazarovici, N. Primor, J. Gennaro, J. Fox, Y. Shai, P.I. Lelkes, C.G. Caratsch, G. Raghunathan, H.R. man, Y.L. Shih, and C. Edwards.
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Additional resources for Marine Toxins. Origin, Structure, and Molecular Pharmacology
Sample text
In summary, analyses for the saxitoxins provide information that, i n principle, is clear and readily interpreted while the design and interpretation o f assays for the saxitoxins is complicated by the multiplicity o f the toxins, their differing properties, and the variations i n toxin composition that w i l l be encountered. Assays, however, can i n principle be very simple to perform while the presently available analyses for the saxitoxins require fairly complex equipment. ; ACS Symposium Series; American Chemical Society: Washington, DC, 1990.
Ref. 10. Origins o f Alexandrium cultures used for the analyses o f toxin c o m p o s i t i o n summarized i n Table I. ch003 HALL ET AL. The Saxitoxins: Sources, Chemistry, and Pharmacology Table I. Toxin Composition of Alexandrium from the Northeast Pacific 0 Toxin Composition Location Strain Dutch Harbor Lost H a r b o r DH07 LH01 Port S a n J u a n PW06 1 2 3/5 4/6 7 ? + + + + + 8 9/11 + + + Elfin Cove EC06 Bartlett C o v e BC07 Porpoise Island PI07 + + -I- Haines HG01 HG27 + + Ketchikan KN03 + San Francisco SF01 SF05 + + + + + + + + + + + + + + + + + + + + + + + + + + + ?
T o clarify the discussion o f structure/activity relationships, this section w i l l attempt to illuminate the practical distinction between the equilibrium dissociation constant, K , and the rate constants, k and k , and their relationship, particularly: d Q n Q f f • Differences i n the equilibrium dissociation constant, K , for the binding o f the various saxitoxins to the sodium channel binding site largely determine the differences i n the potencies o f the toxins i n w h o l e animal assays and i n tissue preparations.