By Juliet V. Spencer, I. Edward Alcamo, David Heymann
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Extra resources for Herpes
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Q 3/10/08 9:49 AM Page 39 Nature’s Design: Virus Structure A VIRUS CAPSID AS A HOME R. Buckminster Fuller was a scientist and philosopher who gained renown as the inventor and designer of the architectural dome. Fuller wished to apply his technological know-how to one of the most basic and persistent problems of humankind— the lack of efficient, affordable human shelter. Building upon the basic principles of science, his structures made use of tension instead of the usual compression. By way of example, Fuller demonstrated how the difference in strength between a rectangle and a triangle could be confirmed by applying pressure to both structures.
7). q 3/10/08 9:50 AM Page 54 5 Lying in Wait: Virus Latency The following letter appeared in a local newspaper: Dear Heloise, Help, I can’t get rid of roaches! I’ve tried so many chemicals the family and pets should be dead. I can’t afford a monthly fee to have someone come in all the time. I’ve emptied every cupboard and have sprayed, powdered and sealed. Nothing works. They leave during the day but at night are back and it seems they bring more friends. My walls, baseboards and cupboards are being ruined by the constant spraying.
Chinese philosopher Sun Tzu’s The Art of War describes how to think about challenges in a new way, not as fighting others, but as advancing your own position to make success inevitable. HSV has mastered this through the art of immune evasion. The secret to the success of this tiny guerrilla warrior is that it is has numerous strategies for thwarting offensive maneuvers by the immune system. For example, a virusinfected cell is usually identified by circulating lymphocytes, cells that defend the body against dangerous invaders, because of a tag displayed on the cell surface.