By Kanniah Rajasekaran, Jeffrey W. Cary, Jesse M. Jaynes, Emilio Montesinos
content material: Immunomodulatory cationic peptide therapeutics : a brand new paradigm in an infection and immunity --
Structure/function hyperlink among cytokine domain names and ordinary and designed lytic peptides : clinical promise --
the opportunity of frog epidermis antimicrobial peptides for improvement into therapeutically worthy anti-infective brokers --
stumbling blocks and suggestions to using cationic antimicrobial peptides within the remedy of melanoma --
Lytic peptides as anti-cancer therapeutics : classes realized from a singular layout technique --
thoughts for designing peptide immunogens to elicit : helical conformation-specific antibodies reactive with local proteins --
Defensins in viral an infection --
"GENOPEP," a topical cream within the remedy of burn wounds --
constructing influenza antigen microarrays for seroprofiling --
pH-directed self-assembling helical peptide conformation --
Controlling symbiotic microbes with antimicrobial peptides --
Antimicrobial peptides for plant illness regulate : from discovery to program --
Antimicrobial peptides as a promising replacement for plant ailment safeguard --
innovations for controlling plant ailments and mycotoxin illness utilizing antimicrobial artificial peptides --
Antifungal plant defensins : structure-activity relationships, modes of motion, and biotech purposes --
Antifungal peptides : exploiting non-lytic mechanisms and phone penetration homes --
Thionin antifungal peptide synthesis in transgenic barley --
Expression of designed anti-microbial peptides in theobroma cacao L. bushes reduces leaf necrosis because of phytophthora spp --
Antimicrobial peptides for hearth blight regulate --
Thionins : nature's guns of mass safeguard --
Transgenic expression of antimicrobial peptides in crops : concepts for improved disorder resistance, enhanced productiveness, and construction of therapeutics.
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Extra resources for Small Wonders: Peptides for Disease Control
Example text
37. ; Mannis, M. ; Cullor, J. ; Schwab, I. ; Jaynes, J; Smith, W. ; Murphy, C. J. In vitro antimicrobial activity of shiva-11 against ocular pathogens. Cornea 1994, 13, 237–42. 38. ; Jaynes, J. ; Blackmon, B. Effect of novel lytic peptides on plant pathogenic fungi. Hortscience 1987, 22, 1057. 39. ; Jaynes, J. ; Clark, C. Effect of novel lytic peptides on plant pathogenic bacteria. Phytopathology 1987, 77, 1768. ; ACS Symposium Series; American Chemical Society: Washington, DC, 2012. ch002 40. Jaynes, J.
Modulation of Angiogenesis and Inflammation by Lytic Peptide Fragments and Specific Cytokine Domains Angiogenesis Angiogenesis is a physiological process that involves the growth of new blood vessels derived from vessels already present. It is a normal process vital for growth and development (85–88). However, disease can result from aberrant blood vessel formation and it is a fundamental step in the transition of tumors from the dormant state to one of malignancy (89). It has been recognized for many years that in order for tumors to grow beyond a small size an abundance of oxygen and nutrients are requisite for their proliferation.
Since the “correct” metabolism of these molecules would vary among individual animals, it is not unexpected that some animals would respond better to treatment than others. The yield of potentially therapeutic fragments generated would be entirely at random and could not be expected to be a consistent process, even within one particular animal. The similarities to results, using D2A21 administered from a remote site are striking and are compatible with the occasional variability of an observed anti-tumor effect.