By Bernd Nilius, Veit Flockerzi
In this fast-paced box the most target of this quantity is to supply up to date details at the molecular and useful houses and pharmacology of mammalian TRP channels. best specialists within the box describe homes of a unmarried TRP protein/channel or painting extra basic rules of TRP functionality and significant pathological occasions associated with mutations of TRP genes or their altered expression. Thereby this quantity on temporary Receptor capability (TRP) Channels offers worthy info for readers with varied expectancies and backgrounds, if you happen to are forthcoming this box of analysis in addition to for these eager to make a visit to TRPs.
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Additional info for Mammalian Transient Receptor Potential (TRP) Cation Channels: Volume II
Sample text
2007; Ko¨hler et al. 2006; Loot et al. 2008). A recent study has shown that TRPV4 located in microdomains of endothelial cells together with Ca2+-activated K+ channels at the myoendothelial junction can also be activated by low intravascular pressure (Bagher et al. 2012). In the lung, Ca2+ entry through endothelial TRPV4 has been implicated to play a role in high vascular pressure-induced lung injury, a process involving the production of EETs (Jian et al. 2008). In addition to its presence in endothelial cells, TRPV4 is also expressed in vascular smooth muscle cells of some arteries.
J Neurosci 25:5109–5116 Aizawa N, Wyndaele JJ, Homma Y, Igawa Y (2012) Effects of TRPV4 cation channel activation on the primary bladder afferent activities of the rat. Neurourol Urodyn 31:148–155 Alessandri-Haber N, Yeh JJ, Boyd AE, Parada CA, Chen X, Reichling DB, Levine JD (2003) Hypotonicity induces TRPV4-mediated nociception in rat. Neuron 39:497–511 Alessandri-Haber N, Dina OA, Yeh JJ, Parada CA, Reichling DB, Levine JD (2004) Transient receptor potential vanilloid 4 is essential in chemotherapy-induced neuropathic pain in the rat.
2002). g. Atiba-Davies and Noben-Trauth 2007), but the channel does not seem to form the mechanotransduction channel (van Aken et al. 2008), and hair cell-specific deletion of TRPML3 does not lead to hearing or balance impairments (Jo¨rs et al. 2010). Conclusions and Outlook From the information presented in this chapter, it is clear that a number of TRP isoforms from different subfamilies have been proposed to be involved in responses to mechanical stimuli. However, for only few of these channels is the evidence supporting this role comprehensive and comprises evidence for mechanical activation in native cells and after heterologous expression, evidence at the biophysical (single channel conductance and channel properties) and molecular level (knockout, knockdown, expression) for channel involvement, knowledge of the activation mechanism (direct, indirect, pathway), and an indication of its possible physiological roles (response to knockout, knockdown).