By R-K Li and R.D. Weisel (Eds.)
Cardiac Regeneration and service, quantity reviews using biomaterials, by myself or mixed with phone treatment, in delivering tissue-engineered constructs to fix the injured middle and stop or opposite middle failure.
Part one explores the diversity of biomaterials to be had for cardiac fix, together with nanomaterials and hydrogels. additional chapters discover using biomaterials to reinforce stem cellphone remedy for restoring ventricular functionality and producing stem cell-modified intravascular stents. half specializes in tissue engineering for cardiac fix, together with chapters on decellularized biologic scaffolds, artificial scaffolds, mobile sheet engineering, maturation of practical cardiac tissue patches, vascularized engineered tissues for in vivo and in vitro functions, and scientific concerns for cardiac tissue engineering. eventually, half 3 explores vascular home improvement, together with chapters highlighting aortic extracellular matrix home improvement, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels.
Cardiac Regeneration and service, quantity Two is complemented by means of an preliminary quantity overlaying pathology and treatments. jointly, the 2 volumes of Cardiac Regeneration and service provide a accomplished source for clinicians, scientists, or academicians enthusiastic about cardiac regeneration, together with these attracted to mobilephone remedy, tissue engineering, or biomaterials.
- Surveys the diversity of biomaterials on hand for cardiac fix, together with nanomaterials and hydrogels.
- Focuses on tissue engineering for cardiac fix together with scientific issues for cardiac tissue engineering
- Explores vascular home improvement, highlighting aortic extracellular matrix home improvement, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels
Read or Download Cardiac Regeneration and Repair. Biomaterials and Tissue Engineering PDF
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Sample text
2003), Shao et al. (2006) and Liu et al. (2006) reported improved ejection fraction in the bFGFgelatin group while Yamamoto et al. (2001) was not able to correlate the neovascularization to a functional benefit. , 2002). , 2011) based hydrogels. Another commonly used angiogenic growth factor is vascular endothelial growth factor (VEGF). To prolong the release of VEGF in infarcted myocardium, Wu et al. (2011) conjugated VEGF to a PEG-based hydrogel with ester groups that allowed for hydrolytic degradation.
In terms of LV geometry, only the stiffer non-degradable hydrogel was able to significantly reduce change in end systolic volume. But this difference in LV remodeling by the hydrogels with different mechanical and degradation properties was not reflected in functional parameters, where ejection fraction was the same for all hydrogels compared with infarct controls. Of the naturally derived hydrogels discussed so far, none have specifically been designed as a cardiac-specific material for tissue regeneration and repair.
The peptide nanofibers (NFs) are generally self-complementary amphiphilic sequences that have repeating units of positively and negatively charged residues separated by hydrophobic residues (Holmes, 2002). As this synthetic polymer is composed of natural building blocks, the resultant material is biodegradable with degradation products that can be used in normal bodily functions. , 1995). , 1993). , 2003). In particular, Davis et al. (2005) showed that intramyocardial injections of peptide NFs into healthy rat hearts promoted recruitment of endogenous endothelial and smooth muscle cells.