By Marco G. Paggi, Armando Felsani, Antonio Giordano (auth.), Wafik S. El-Deiry MD, PhD (eds.)

Powerful new instruments at the moment are on hand to find and comprehend tumor suppressor genes (TSGs) and the biochemical mechanisms in which they regulate melanoma improvement and development. In Tumor Suppressor Genes, quantity 1: Pathways and Isolation recommendations, major health practitioner scientists and educational researchers evaluation all of the identified tumor suppressor genes, clarify how they paintings, and describe how they have been chanced on and remoted. in lots of instances, the authors talk about particular genes which are usually curious about hereditary or sporadic cancers. additionally they supply a close consultant to utilizing strong molecular genetic, cytogenetic, proteomic, and mobilephone organic concepts to isolate and signify novel tumor suppressor genes and their pursuits. The spouse quantity of this set, Tumor Suppressor Genes, quantity 2: legislation, functionality, and Medicinal purposes, demonstrates how top to discover the cellphone biology and biochemical functionality of such genes, and their encoded proteins, to check their physiological position in vivo, and to take advantage of info on TSGs to strengthen diagnostic and healing suggestions for cancer.
accomplished and authoritative, the 2 volumes of Tumor Suppressor Genes offer an remarkable compilation of key info on all recognized tumor suppressor pathways and a treasury of ideas for his or her discovery, research, and makes use of in melanoma therapeutics.

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Johnson, K. , Smith, K. , Hill, D. , and Kinzler, K. W. (1993) Association between wild type and mutant APC gene products. Cancer Res. 53, 2728–2731. 49. , Richardson, D. , and Alber, T. (1993) Dimer formation by an N-terminal coiled coil in the APC protein. Proc. Natl. Acad. Sci. USA 90, 11109–11113. 50. , and Karran, P. (1994) Genetic steps in colorectal cancer. Nat. Genet. 6, 217–219. 51. , and Doeberitz, M. V. (1999) Dominant negative effect of the APC(1309) mutation: a possible explanation for genotype-phenotype correlations in familial adenomatous polyposis.

H. and Groden, J. (2000) Biology of the adenomatous polyposis coli tumor suppressor. J. Clin. Oncol. 18, 1967–1979. 21. , et al. (1996) Long-range physical map and deletion characterization of the 1100-kb NotI restriction fragment harboring the APC gene. Genomics 34, 268–270. 22. , and Ballhausen, W. G. (1995) Multiple APC messenger RNA isoforms encoding exon 15 short open reading frames are expressed in the context of a novel exon 10A-derived sequence. Int. J. Cancer 63, 435–441. 23. Sieber, O.

1996) Lessons from hereditary colorectal cancer. Cell 87, 159–170. 106. , et al. (1992) The APC gene, responsible for familial adenomatous polyposis, is mutated in human gastric cancer. Cancer Res. 52, 3231–3233. 107. , and Ishikawa, T. (1996) Somatic mutations of the APC gene in sporadic hepatoblastomas. Cancer Res. 56, 3320–3323. 108. , et al. (2000) Somatic mutations of the APC gene in primary breast cancers. Am. J. Pathol. 156, 1997–2005. 109. Morin, P. , Sparks, A. , et al. (1997) Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC.

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