By Lieping Chen

The B7-CD28 family members molecules are the most intensively studied receptor-ligand structures within the box of immunology. this is often glaring from the explosive accumulation of literature, rather within the final ten years. fresh years have witnessed speedy discoveries and characterization of latest receptors and ligands within the relations. those new pathways, even supposing nonetheless of their infancy, have already introduced a lot pleasure to the sector. even though, earlier, there was no unmarried quantity to hide this complete sector. This ebook used to be created to assemble state of the art info and important pondering from the best investigators. This e-book covers major territory of this swiftly relocating box from structural biology and biochemical signalling to immunological features and their power purposes within the remedy of human illnesses. this is often a superb guide and reference for immunologists, future health pros in addition to clinical scholars and graduate scholars in existence technological know-how box.

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Extra resources for The B7-CD28 Family Molecules (Molecular Biology Intelligence Unit)

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Curr Biol 1998; 8:563-572. 81. Ebinu JOI, Bottorff DA, Chan EY et al. Ras GRP, a Ras guanyl nucleotide-releasing protein with calcium and diacylglycerol-binding motifs. Science 1998; 280:1082-1086. 82. Raab M, Pfister S, Rudd CE. CD28 signaling via Vav/SLP-76 adaptors: regulation of cytokine transcription independent of TCR ligation. Immunity 2001; 15:921-33. 83. Raab M, da Silva AJ, Findell PR et al. Regulation of Vav–SLP-76 Binding by ZAP-70 and Its Relevance to TCRζ /CD3 Induction of Interleukin-2.

J Exp Med 1999; 190(6):765-774. 120. Cinek T, Sadra A, Imboden JB. Tyrosine-independent transmission of inhibitory signals by CTLA-4. J Immunol 2000; 164(1):5-8. 121. Baroja ML, Luxenberg D, Chau T et al. The inhibitory function of CTLA-4 does not require its tyrosine phosphorylation. J Immunol 2000; 164(1):49-55. 122. Carreno BM, Bennett F, Chau TA et al. CTLA-4 (CD152) can inhibit T cell activation by two different mechanisms depending on its level of cell surface expression. J Immunol 2000; 165:1352-1356.

JBC 1996; 271:1591-1598. 49. Kim HH, Tharayil M, Rudd CE. Growth factor receptor-bound protein 2 SH2/SH3 domain binding to CD28 and its role in co-signaling. JBC 1998; 273:296-301. 50. Yang W-C, Ghiotto M, Barabarat B et al. The role of Tec protein tyrosine kinase in T cell signaling. JBC 1999; 274:607-617. 51. Liao XC, Fournier S, Killeen N et al Itk negatively regulates induction of T cell proliferation by CD28 costimulation. J Exp Med 1997; 186:221-228. 52. Yang W-C, Olive D. Tec kinase is involved in transcriptional regulation of IL-2 and IL-4 in the CD28 pathway.

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