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Extra info for Rita Levi-Montalcini: Discoverer of nerve growth factor
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He is shown here in 1969, the year he won the Nobel Prize in physiology or medicine for his work on the genetics of bacteria and viruses. (National Library of Medicine) Rita Levi-MontaLcini (continued from previous page) of a friend (and, unknowingly at the time, Delbrück’s lead as well), Luria began to study the genes of bacteriophages, a group of viruses that infect bacteria. Failing to find work in Italy because of the Fascist government’s increasingly repressive policies against Jews, Luria moved first to France in 1938 and then, when the Germans invaded that country in 1940, to the United States.
He graduated from medical school in the same year as LeviMontalcini, even though he was five years younger. During the German occupation of Italy he served as a physician to a partisan group. Dulbecco worked with Luria in Indiana for two years, then moved to Caltech to collaborate with Max Delbrück, whom he had met through Luria. Dulbecco studied bacteriophages for several years, then began examining viruses that infect animals. He and his students demonstrated that some viruses caused cancer in animals by inserting certain genes into the genomes of the cells they infected.
In his experiments with Levi-Montalcini, Fabio Visintini recorded the electrical activity of the chick embryos’ neurons, both the signals that the cells generated spontaneously and the ones they produced when stimulated through electrodes. LeviMontalcini, meanwhile, used her version of the silver stain to bring out the physical changes that occurred in groups of neurons as they matured into their final form, or differentiated. Together the two researchers created a detailed, day-by-day picture of the changes that occurred as a chicken’s nervous system developed.
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