By Elisabeth M. T. Wurm, Hans Peter Soyer (auth.), Rainer Hofmann-Wellenhof, Giovanni Pellacani, Joseph Malvehy, Hans Peter Soyer (eds.)
This publication specializes in the use and value of in vivo reflectance confocal microscopy (RCM) for non-invasive high-resolution imaging of the outside. all the chapters during this hands-on advisor are generously illustrated with various confocal photos and established in a reader-friendly manner. The contents contain specified info at the such a lot proper and updated features of RCM, schematic drawings summarizing and explaining crucial RCM standards, and a bankruptcy in particular dedicated to bridging the distance among dermoscopy, RCM, and histopathology. on the finish of every bankruptcy, center messages recapitulate the main pertinent features. Reflectance Confocal Microscopy for dermis Diseases can be a useful source for all physicians interested by the analysis and remedy of neoplastic and inflammatory pores and skin diseases.
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Extra info for Reflectance Confocal Microscopy for Skin Diseases
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J Am Acad Dermatol 57:644–658 31 4. Calzavara-Pinton P, Longo C, Venturini M, Sala R, Pellacani G (2008) Reflectance confocal microscopy for in vivo skin imaging. Photochem Photobiol 84:1421–1430 5. Rajadhyaksha M, Grossman M, Esterowitz D, Webb RH, Anderson RR (1995) In vivo confocal scanning laser microscopy of human skin: melanin provides strong contrast. J Invest Dermatol 104: 946–952 6. Rajadhyaksha M, González S, Zavislan JM, Anderson RR, Webb RH (1999) In vivo confocal scanning laser microscopy of human skin II: advances in instrumentation and comparison with histology.
Dermal dense nests, regular homogeneous: oval compact aggregates, within the dermal papillae and not connected with the epidermis 54 B. Ferrari et al. Dense & sparse nest Large dermal cluster showing not tightly aggregated cells within the nest. Large aggregate and cell monomorphism are suggestive of intradermal component in a melanocytic nevus. Frequently observable in intradermal and congenital nevi. Fig. 5 mm). Large dense & sparse nest: it is constituted by a large aggregate of roundish monomorphic cells fulfilling the dermal papilla Dense & sparse nest Dermal cluster showing not tightly aggregated cells within the nest and pleomorhism.
Routine histology reveals elongated rete-ridges with an increased number of melanocytes in the basal layer and pigmented basal keratinocytes corresponding to a lentiginous pattern. On the other hand, pigment network with an underlying “meshwork pattern” is characterized by a predominance of junctional thickenings, corresponding to enlargements of interpapillary spaces formed by compact aggregated cells. This pattern shows on histopathology nested junctional pattern with predominantly small, non-confluent, discrete nests at the tips of the rete ridges.