By Caroline Köhrer; Uttam RajBhandary
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Extra resources for Protein engineering
Sample text
J Biol Chem 276:11517–11523 Understanding Enzyme Mechanism through Protein Chimeragenesis 25 Eisenmesser EZ, Bosco DA, Akke M, Kern D (2002) Enzyme dynamics during catalysis. Science 295:1520–1523 Fierke CA, Johnson KA, Benkovic SJ (1987) Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli. Biochemistry 26:4085–4092 Garcia-Viloca M, Gao J, Karplus M, Truhlar Donald G (2004) How enzymes work: analysis by modern rate theory and computer simulations.
1 Chemical versus Ribosomal Synthesis . . . . . . . . . . . . . . . . . . . 2 Side Chain Modifications . . . . . . . . . . . . . . . . . . . . . . . . 4 Enzyme-Mediated Peptide Bond Formation . . . . . . . . . . . . . . . . . . . References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29 30 30 31 32 34 36 41 42 43 44 45 47 55 58 Abstract Chemical engineering of proteins provides a pool of various synthetic and semisynthetic methods.
The thioesters accessible by this recombinant technique may also serve for the synthesis of (diphenylphosphinyl) methane thioesters as intermediates in the traceless Staudinger ligation (Nilsson et al. 2003). , the endogenous methionyl-peptidases of Escherichia coli or proteases such as factor Xa; for more details see the chapter by Imperiali and Vogel Taylor, this volume). 7 Amide Bonds Generated by Decarboxylative Condensation A decarboxylative condensation of α-keto carboxylic acids and N-alkylhydroxylamine derivatives may well represent a promising amide-forming reaction for ligation chemistry (Bode et al.