By R. D. Myers (auth.), Leslie L. Iversen, Susan D. Iversen, Solomon H. Snyder (eds.)
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Extra resources for Principles of Receptor Research
Sample text
From Sharpe and Myers (1969). chemical which acts ata site, (3) the pH of the substance, (4) the temperature, (5) the osmolarity, and (6) the extent of diffusion. Figure 5 recapitulates diagrammatically the method itself. The validity of any interpretation about the morphological specificity of a chemical's action depends entirely on histological localization of the site of injection. As one can readily imagine, if a volume greater than 2 or 3 JLI is infused, the solution simply takes the path of least resistance and enters the ventricle or subarachnoid space.
In the outflow tube, the perfusate flows back into the pull syringe. The diagram is not to scale because of the smallness of some of the parts. From Myers (1970). Generally, the push-pull cannula assembly is constructed in a concentric manner (Myers, 1967), as shown in Fig. 7. That is, the smaller push cannula rests inside the pull cannula, which has a much larger inside diameter, thus providing a clear passageway for withdrawal of the effluent. The alternative cannula configuration is the side-by-side version pioneered 24 R.
Second, some chemical compounds diffuse to a lesser degree than a liquid when placed in the brain parenchyma; hence anatomical localization is, in some instances, more feasible. Third, it is more convenient insofar as benchwork preparation is concerned than the injection of a solution (albeit convenience and science have no relationship). A number of clever procedures for cannulation have been developed including those for (1) delivering crystals at different depths, (2) ejecting a pellet at any time in the course of an experiment, and (3) fusing crystalline hormone to different-size chemitrodes.