By Chiara Gualandi
The improvement and alertness of bioactive nano-structured constructs for tissue regeneration is the point of interest of the learn summarised during this thesis. furthermore, a specific concentration is the rational use of supercritical carbon dioxide foaming and electrospinning applied sciences which may end up in leading edge polymeric bioresorbable scaffolds made up of hydrolysable (both advertisement and ‘ad-hoc’ synthesized) polyesters. generally, the writer discusses the manipulation of polymer chemical constitution and composition to track scaffold actual houses, and optimization of scaffold 3D structure through a wise use of either fabrication concepts. The multidisciplinary nature of this learn is crucial in pursuing the problem of tissue regeneration effectively. one of many strengths of this thesis is the mixing of data from chemistry, physics, engineering, fabrics technology and biomedical technology which has contributed to constructing new nationwide and overseas collaborations, whereas strengthening current ones.
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Extra info for Porous Polymeric Bioresorbable Scaffolds for Tissue Engineering
Sample text
34, by C. 1a Poly((D,L)lactideco-glycolide) [PLA50GA50] LA:GA = 50:50 Institute of polymers and carbon materials, polish academy of science (Zabrze, Poland) Institute of polymers and carbon materials, polish academy of science (Zabrze, Poland) Boehringer (Ingelheim, Germany) D:L = 50:50 LA:GA = 65:35 Poly((L)lactideLA:TMC = 70:30c co-trimethylene carbonate) (Resomer LT 706) [P(LA-TMC)] Poly(e-caprolactone) (787 – Union carbide Co. 1% w/V at 25 °C e measured by GPC in ortho-dichlorobenzene at 135 °C by using polystyrene standards f provided by the supplier GPC in DMF at 70 °C, by using polymethylmetacrilate standards), was synthesized as previously described [6].
Erisken C, Kalyon DM, Wang H (2008) Functionally graded electrospun polycaprolactone and b-tricalcium phosphate nanocomposites for tissue engineering applications. Biomaterials 29:4065 170. Fujihara K, Kotaki M, Ramakrishna S (2005) Guided bone regeneration membrane made of polycaprolactone/calcium carbonate composite nano-fibers. Biomaterials 26:4139 171. Sui G, Yang X, Mei F, Hu X, Chen G, Deng X, Ryu S (2007) Poly-L-lactic acid/ hydroxyapatite hybrid membrane for bone tissue regeneration. J Biomed Mater Res 82A:445 172.
Adv Funct Mater 15:1988 173. Lee SJ, Yoo JJ, Lim GJ, Atala A, Stitzel J (2007) In vitro evaluation of electrospun nanofiber scaffolds for vascular graft application. J Biomed Mater Res 83:999 174. Stitzel J, Pawlowski KJ, Wnek GE, Simpson DG, Bowlin GL (2001) Arterial smooth muscle cell proliferation on a novel biomimicking, biodegradable vascular graft scaffold. J Biomater Appl 16:22 175. Stitzel J, Lee SJ, Komura M, Berry J, Soker S, Lim G, Dyke MV, Czerw R, Yoo JJ, Atala A (2006) Controlled fabrication of a biological vascular substitute.
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