By Jens Thiele, Peter Elsner
Are unfastened radicals and reactive oxygen species suitable to dermatopathology? Do antioxidants guard opposed to free-radical-mediated cutaneous ailments and getting older? to those and extra present questions within the swiftly progressing box of easy and utilized pores and skin learn, this updated quantity offers a systematic foundation. It offers cutting-edge experiences at the development in detection of unfastened radicals and antioxidants and their responses to environmental oxidative stressors. additionally, numerous specialist contributions specialise in the interesting advancements in oxidative DNA harm and UVB- and UVA-induced sign transduction in pores and skin. eventually, details is given on new antioxidant safeguard concepts opposed to epidermis carcinogenesis and epidermis getting older that may be primary for the pharmaceutical or skin-care items of the following day.
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Additional resources for Oxidants and Antioxidants in Cutaneous Biology (Current Problems in Dermatology)
Sample text
Blanc D, Saint-Leger D, Brandt J: An original procedure for quantification of cutaneous resorption of sebum. Arch Dermatol Res 1989;281:346–350. Faergemann J, Godleski J, Laufen H, Liss RH: Intracutaneous transport of orally administered fluconazole to the stratum corneum. Acta Derm Venereol 1995;75:361–363. Fuchs J: Oxidative Injury in Dermatopathology. Berlin, Springer, 1992. Picardo M, Zompetta C, De Luca C, Amantea A, Faggioni A, Nazzaro-Porro M, Passi S: Squalene peroxides may contribute to ultraviolet light-induced immunological effects.
The upper spectrum is of human skin topically treated with 100 l of 10 mM Desferal for 10 min followed by exposure to UV radiation. Both spectra are the result of 5 signal-averaged scans. Asc•Ö, was observable in both treatment groups. Desferal reduced the DMPO radical signal by 50% (fig. 2), which parallels earlier observations in mouse skin [9]. Discussion It has been demonstrated that the ascorbate radical EPR signal can serve as an indicator of oxidative events [6, 9, 13]. In both mouse and human skin biopsies, the Asc•Ö signal intensity increases with UV radiation exposure, indicating oxidative stress.
B Release of DHLA into cell culture medium in the presence of keratinocytes. 2 mM -lipoic acid was added to the culture medium. Already after 30 s, small amounts of DHLA are detectable in the medium (means×SD, n>3). tissue specific and effects of exogenously supplied -lipoic acid are determined by tissue glutathione reductase and dihydrolipoamide dehydrogenase activity.