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Fleming FJ, Myers E, Kelly G, Crotty TB, McDermott EW, O’Higgins NJ, Hill AD, Young LS (2004) Expression of SRC-1, AIB1, and PEA3 in HER2 mediated endocrine resistant breast cancer; a predictive role for SRC-1. J Clin Pathol 57:1069–1074 89. Qin L, Liu Z, Chen H, Xu J (2009) The steroid receptor coactivator-1 regulates twist expression and promotes breast cancer metastasis. Cancer Res 69:3819–3827 90. Hurtado A, Holmes KA, Geistlinger TR, Hutcheson IR, Nicholson RI, Brown M, Jiang J, Howat WJ, Ali S, Carroll JS (2008) Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen.
Moreover, they demonstrated that Ada3 is necessary for Gcn5-dependent nucleosomal HAT activity in yeast extracts and is important for expanding the lysine specificity of the ADA complex [42]. Similar to yeast, studies with mammalian Gcn5, Ada2b (present in STAGA complex), and Ada3 proteins have shown that these proteins can form a heterotrimer in vitro and can efficiently acetylate nucleosomal 2 Role of Alteration/Deficiency in Activation (ADA) Complex in Cell Cycle… 37 arrays [43]. Unlike yeast proteins, neither Ada2b nor Ada3 was demonstrated to enhance the acetylation of free-core histones by mammalian Gcn5 in vitro.
Gene 245:1–11 12. Kim JH, Li H, Stallcup MR (2003) CoCoA, a nuclear receptor coactivator which acts through an N-terminal activation domain of p160 coactivators. Mol Cell 12:1537–1549 13. Belandia B, Orford RL, Hurst HC, Parker MG (2002) Targeting of SWI/SNF chromatin remodelling complexes to estrogen-responsive genes. EMBO J 21:4094–4103 14. Askew EB, Bai S, Hnat AT, Minges JT, Wilson EM (2009) Melanoma antigen gene proteinA11 (MAGE-11) F-box links the androgen receptor NH2-terminal transactivation domain to p160 coactivators.