By X. He, V. Neugebauer, H.-G. Schaible (auth.), Prof. Dr. K. Brune (eds.)

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Drugs 32 (suppi. 4). 129-147. 1986. 9. Vanacek, J•• Antipyretic analgesics. G. ). Side effects of drugs. Elsevier. Amsterdam 1985. pp. 75-82. 10. Starlco. M.. Ray. • Dominguez. • et aI.. Reye's syndrome and salicylate use. 1980. II. • McGee. • Aspirin as a risk factor in Reye's syndrome. JAMA 247:3089-3094. 1982. 12. Halpin. • Holtzhauer. • Campbell. • Reye's syndrome and medication use. 1982. 13. Hurwitz. • Bergman. • Public Health Service study on Reye's syndrome and medications. Report of the pilot phase.

However, restriction of the sales of analgesic mixtures containing combinations of aspirin, phenacetin, paracetamol, salicylamide and caffeine seems to be effective. Levy Still, today, 37 years after analgesic nephropathy was flrst described by Spuhler and Zollinger [20], many questions remain open. What is the role in nephropathy of aspirin, a drug convincingly shown in experiments done by Kincaid-Smith and her group to cause papillary necrosis, and what is the excess risk for the various drug combinations?

The period of aetiological significance, was compared between 221 confirmed cases of agranulocytosis and 1425 hospital controls identified by the study centres in Jerusalem, Berlin, Vlm, Milan, Barcelona, Sofia, Budapest and Stockholm. The study base comprised the total experience in these areas during the 1980-1984 period, which amounted to close on 80 million person-years. 0). 0). There was a significant regional variability in the rate ratio estimate for the use of dipyrone. 9). In Budapest and Sofia the estimates were close to unity, in Milan data were too sparse, while in Stockholm dipyrone was not in use.

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