By Yi Ge, Songjun Li, Shenqi Wang, Richard Moore

Increasing call for for and knowledge of the functions of nanotechnology in drugs has led to the emergence of a brand new fast-growing multidisciplinary region - nanomedicine. This ebook deals accomplished wisdom of and various views on nanomedicine via self sufficient volumes. It goals to bridge the space among nanotechnology and drugs via contributions by way of world-renowned specialists from wide selection of backgrounds together with academia, undefined, expert consultancy, and govt agencies.

Each contribution integrates wisdom from quite a lot of parts to provide the basics of recent functions and items of nanomedicine, in addition to an outlook for the long run. This publication can good function a reference and advisor for college kids, teachers, researchers, scientists, engineers, clinicians, govt researchers, and healthcare professionals.

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J Biomater Sci Polym Ed 15(9):1181–1202 2 Nanobiology in Medicine 31 56. Chowdhury E, Akaike T (2005) Bio-functional inorganic materials: an attractive branch of gene-based nano-medicine delivery for 21st century. Curr Gene Ther 5(6):669–676 57. Bhavsar M, Amiji M (2007) Polymeric nano- and microparticle technologies for oral gene delivery. Expert Opin Med Delivery 4(3):197–213 58. Pan B, Cui D, Sheng Y et al (2007) Dendrimer-modified magnetic nanoparticles enhance efficiency of gene delivery system.

In 2005, Shen et al. studied polymerase chain reaction (PCR) of nanoparticle-bound primers [41]. They concluded that with either one or two primers respectively bound to the nanoparticle surface, PCR could proceed completely under optimized conditions, having been subjected to certain rules [41]. Kalogianni et al. reported a simple and inexpensive assay that allowed visual detection and demonstration of the PCR-amplified sequences by hybridization within minutes [42]. According to their study, the nanoparticles bound to the target DNA through hybridization, and the hybrids were captured by immobilized streptavidin at the test zone of the strip, producing a characteristic red line [42].

The protein precipitation systems to qualitatively test the protein in body fluids are the best example for naked eye detection system. The colour changing property of nanomaterials due to aggregation of particles can be applied to diagnostic tests in medicine [29]. Wiwanitkit et al. proposed gold nanoparticle as an alternative tool for the detection of microalbuminuria [12, 13]. Normal urine triggers the precipitation of gold nanoparticle solution resulting in a gray coloured mixture, while urine samples with protein do not.

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