By E. Van Obberghen, R. Ballotti, Y. Le Marchand-Brustel, J. C. Scimeca (auth.), Prof. Dr. Angelo Azzi, Prof. Zdenek Drahota, Prof. Sergio Papa (eds.)

Biological membranes are frequently effected via ailments. Molecular occasions resulting in or bobbing up from pathological alterations during diversified ailments are as but now not essentially understood. This efficient examine by way of top specialists covers alterations of the mobile setting, membranes and the metabolic features in the course of tissue progress and differentiation in addition to elements of irregular organelle functionality in lysosomal garage illnesses, peroxisomal and mitochondrial problems, enzyme defects and regulatory defects of receptors because of oncogenes.

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Nature (London) 304:35-39 Zachary I, Woll PJ, Rozengurt E (1987) A role of neuropeptides in the control of cell proliferation. M. F. DIRENZO,G. GAUDINO,S. GIORDANO,L. NALDINI and C. PONZETIO 1 Growth Factors, Receptors and Oncogenes The discovery of a link between known oncogenes and growth factors, their receptors and their signalling mechanisms has renewed hopes that the basic features of cancerous growth can be understood. ding could provide novel means of diagnosing and treating cancer. It is now established that several ofthe so-called activated oncogenes are altered versions of genes encoding proteins involved in the intercellular and intracellular signalling pathways (for reviews, see Bishop 1983; Hunter 1984; James and Bradshow 1984; Ben-Neriah and Baltimore 1986).

1978; Schwab et al. 1979). However, evidence for a trophic role ofNGF in the central nervous system became apparent when it was shown that the cholinergic neurons of the basal forebrain nuclei express NGF receptors and exhibit specific retrograde transport ofNGF (Schwab et al. 1979; Seiler and Schwab 1984). The cholinergic neurons have also been shown to respond to NGF with an increase in the levels of choline acetyltransferase (ChAT), the enzyme responsible for synthesis of the cholinergic neurotransmitter acetylcholine.

Thoenen et al. 1987). In contrast to sympathetic neurons in the peripheral nervous system, central adrenergic neurons neither respond to NGF nor carry NGF receptors (Konkol et al. 1978; Schwab et al. 1979). However, evidence for a trophic role ofNGF in the central nervous system became apparent when it was shown that the cholinergic neurons of the basal forebrain nuclei express NGF receptors and exhibit specific retrograde transport ofNGF (Schwab et al. 1979; Seiler and Schwab 1984). The cholinergic neurons have also been shown to respond to NGF with an increase in the levels of choline acetyltransferase (ChAT), the enzyme responsible for synthesis of the cholinergic neurotransmitter acetylcholine.

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