By H. Tedeschi
In the earlier few years, the physique of experimental paintings at the constitution, functionality and meeting techniques of mitochondria has extended quickly. nobody individual can think himself or herself thoroughly in charge of the burgeoning literature with no owning severe omissions or blind spots. within the current monograph i've got tried a serious review of the literature. i think that the typical thread of unmarried authorship outweighs the shortcomings of 1 individual featuring many disparate viewpo,ints. it truly is my wish that the tip product represents a entire and coordinated assessment of the subject material to the current date. even supposing the majority of this monograph was once accomplished via October 1974, i've got made a few makes an attempt to replace numerous of the sections at later occasions. Albany, N. Y. , November 1975 H. TEDESCHI Contents A. constitution of Mitochondria 1. normal association . a) traditional skinny part Electron Microscopy b) unfavorable Staining innovations . three c) Freeze-Cleavage . . . . . . . four 2. certain association and Inclusions 10 a) Prismatic or unusual Cristae 10 b) Filaments and Tubules . . eleven c) Amorphous Inclusions 12 d) Intramitochondrial Granules 12 e) DNA Containing Fibers 14 three. Topography of the Mitochondrial Transducing platforms 15 B. The meeting of Mitochondria 18 1. Mitochondrial DNA and Its Genetic function 19 2. Transcription of the Mitochondrial DNA . 28 a) mRNA . . . . . . . . . . . . . . 30 b) The equipment for Transcription and Translation 32 c) Turnover of Mitochondrial RNA 36 three. Protein Synthesis . . . . . . . . 37 a) Mitochondrial Protein Synthesis and Its features 37 b) position of Mitochondrial Protein Synthesis . .
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Additional info for Mitochondria: Structure, Biogenesis and Transducing Functions
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See SCHATZ and MASON 1974). Three of these are associated with cytochrome oxidase, four with rutamycin (or oligomycin)sensitive ATPase and one with cytochrome b. Probably some component or components of the adenine nucleotide translocator are also synthesized in the mitochondria (see HASLAM et al. 1974 a) (see Section B 3 b). The nature of the remaining polypeptides is still in question. As already discussed mitochondrial RNA containing a poly-A sequence is thought to correspond to mRNA. Upon fractionation with acrylamide gel electrophoresis, eight distinct species can be recognized (HIRSCH et al.
1973), ribosomal RNA cistrons (NAGLEY et ai. 1974 a) and drug resistance markers (LAZOWSKA et al. 1974). Electron microscope observations of single stranded DNA in petite yeast show that in at least some mutants, portions of the DNA appear double stranded after denaturation, indicating that there are some reiterated segments which are inverted and adjacent to each other (LOCKER et ai. 1974). Selective reiteration characteristic of mitochondrial DNA mutagenesis suggests the possibility of purifying and amplifying specific mitochondrial genes by selecting the appropriate mitochondrial mutants as an experimental tool in elucidating the genetic properties of the mitochondrial DNA (see NAGLEY et ai.
In this figure the displacement loops are marked by arrows. The E strand is shown in part c of the figure. Part e shows a double length circle (see below). Two arguments can be used to support this interpretation (KASAMATSU et al. 1971 b). The E strand only hybridizes to the light strand of the mitochondrial DNA. In addition, in a strain of mouse containing a high proportion of double length circles, some molecules have two D loops, one monomer length apart (Fig. 6 c) (KASAMATSU et al. 1971 b).