By Mark Anderson, Donald Heistad, Richard E. Kerber, Kanu Chatterjee

Guide of Electrophysiology is a entire consultant to cardiac electrophysiology, introduced jointly by means of a workforce people dependent specialists during this box. The publication specializes in present realizing and the newest advances in electrophysiology. such as sixteen chapters, the ebook starts off with simple figuring out of the mechanisms of arrhythmia (irregular heartbeat), the pharmacology of antiarrhythmic medicines, and an advent to electrophysiology experiences. numerous arrhythmias are mentioned intimately, from tachycardia and bradycardia to cardiomyopathy and Brugada Syndrome. The latter a part of the e-book offers a couple of healing directions for middle stipulations, together with surgical and catheter ablation of cardiac arrhythmias, cardiac resynchronisation remedy and ambulatory electrocardiographic tracking. With 350 complete color photos and illustrations improving sensible suggestion at the prognosis and treatment of cardiac ailments, guide of Electrophysiology presents fundamental suggestions for physicians, clinicians and cardiologists. Key issues * crucial advisor to cardiac electrophysiology from a workforce of specialists on the Universities of California and Iowa * Discusses the newest advances within the box * presents healing instructions for a few middle stipulations *350 complete color photos and illustrations

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Class I Antiarrhythmic Drugs: Sodium Channel Blockers The class I antiarrhythmic drugs primarily act by slowing conductance of sodium (Na +) across the cell membrane. These drugs, therefore, interfere with the depolarization phase of the cardiac action potential (“phase 0”) and also decrease responsiveness to excitation (reduction in Vmax). The magnitude of Na+ channel blockade is determined by specific cardiac tissue, specific drug properties, heart rate, autonomic (parasympathetic and sympathetic) activation, ischemic state and the state of depolarization, among others.

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13. Colquhoun D, Neher E, Reuter H, et al. Inward current channels activated by intracellular Ca in cultured cardiac cells. Nature. 1981;294:752-4. 14. Papazian DM, Schwarz TL, Tempel BL, et al. Cloning of genomic and complementary DNA from Shaker: a putative potassium channel gene from Drosophila. Science. 1987;237:749-53. 15. Timpe LC, Schwarz TL, Tempel BL, et al. Expression of functional potassium channels from Shaker cDNA in Xenopus oocytes. Nature. 1988;331:143-5. 16. Doyle DA, Morais CJ, Pfuetzner RA, et al.

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