By Ai-Lean Chew, Howard I. Maibach
Irritant dermatitis is a standard situation, accounting for an important percentage of occupational pores and skin sickness. the hot creation of non-invasive dermis bioengineering know-how has sped up dermatology learn during this box. This publication includes an exhaustive reference textual content on irritant touch dermatitis, protecting all features of the : medical positive factors, epidemiology, prevention and remedy, analysis, mechanisms, pathology and regulatory matters. The booklet additionally provides novel in vitro and in vivo study thoughts and findings. As irritant dermatitis impacts a number of specialties, the viewers for this publication is vast, together with medical and investigative dermatologists, allergists, toxicologists, pharmaceutical scientists, occupational and environmental physicians, public future health physicians, cosmetologists and pores and skin bioengineers.
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Additional resources for Irritant Dermatitis
Example text
In irritant reactions the specificity was 100% but the sensitivity was only 46%. By multiple regression analy- 13 14 S. Iris Ale, Howard I. Maibach sis, an index could be calculated: 4 X necrosis—3 X edema –2. Subzero values denoted irritancy, while values above zero indicated allergy. Both allergic and irritant challenges induce epidermal proliferation, but the dynamics are different. The expression of keratin 16 (K16), a molecule that is present in the suprabasal epidermis under hyperproliferative conditions, and involucrin, a marker of terminal differentiation, were found to be significantly different 2 and 3 days after challenge with an allergen compared with the irritant SLS.
Hairdressers hand dermatitis. Interdigital dermatitis does not occur predominantly in those with constitutionally sensitive (atopic) skin, including the subset of persons with atopic palmoplantar eczema. This emphasizes the relative importance of occupational wet work as a cause or indirectly the potential benefit of improved skin protection at the workplace. , a pattern of early skin damage as a precursor of more severe irritant contact dermatitis [44]. 5% response) was recruited in 15 vocational training schools in Northwest Germany in the years 1992, 1993, and 1994 and followed-up for the duration of their training.
They become anucleate at the top, forming the 10-µm thick stratum corneum, the outermost barrier to the desiccated environment. This barrier must not only protect against water loss, but also against the entrance of organisms and anthropogenic and/or natural toxins [8]. About 40 years ago the stratum corneum was not considered to be relevant for barrier function. About 30 years ago the “plastic wrap” concept of the stratum corneum emerged, because isolated sheets of stratum corneum possesses great tensile strength and low rates of water permeability [39].