By Maurice N Collins
Hyaluronic acid (HA) is located in extracellular tissue in lots of elements of the physique. it's a fabric of accelerating significance to biomaterials technological know-how and is discovering functions in various parts starting from tissue tradition scaffolds to beauty fabrics. Its houses, either actual and biochemical, in resolution or hydrogel shape, are super appealing for varied applied sciences concerned about physique repair.
This publication considers the fabrics technology at the back of a few of the vital biomedical and healing functions which are rising for HA. Key features resembling its mechanical houses, organic functionality and degradation are mentioned. the most recent applied sciences in chemical amendment and crosslinking techniques are analysed and rising purposes in tender and difficult tissue fix are highlighted. the 1st aim of the publication, which is composed of a set of chapters from best researchers around the globe, is to spotlight the position of HA established hydrogels as scaffolds in maintaining stem cells for transplantation and regrowth. the second one aim is to aspect the numerous impact of HA derived fabrics within the most recent advances in melanoma treatment, basic therapeutics and cosmetics. The 3rd goal is to hyperlink the structure-property relationships of HA to scientific functionality and alertness whereas reflecting on present scientific and marketplace trends.
The e-book can be of curiosity to these serious about HA examine for clinical machine and healing functions. Graduate and undergraduate scholars engaged within the fields of biomedical engineering, fabrics technology, chemistry, scientific technological know-how, pharmaceutical technology and polymer technological know-how will locate this booklet of specific interest.
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Additional info for Hyaluronic acid for biomedical and pharmaceutical applications
Example text
Farach-Carson, PLoS One, 2012, 7, e50075. 54. Y. Lei, S. Gojgini, J. Lam and T. Segura, Biomaterials, 2012, 32, 39. 18 Hyaluronic Acid Hydrogel: A Favourable Niche for Neural Stem Cells 55. S. Ouasti, R. Donno, F. J. Sherratt, G. Terenghi and N. Tirelli, Biomaterials, 2011, 32, 6456. 56. R. L. Wagner, R. B. Bjugstad, Stem Cell Research, 2014, 12, 11. 57. K. Z. R. D. E. B. Shear and C E. Schmidt, Biomaterials, 2010, 31, 3930. 19 Hyaluronic Acid for Biomedical and Pharmaceutical Applications 20 2 Hyaluronic Acid Incorporation into Scaffolds for Bone and Cartilage Regeneration Abhijith K.
Ilagan, T. Knight, T. J. J. Jayo, D. W. Ludlow and C. Halberstadt, Cell Transplant, 2011, 20, 1771. 45. A. Goubko, A. Basak, S. Majumdar and X. Cao, Journal of Biomedical Materials Research Part A, 2013, 102, 381. 46. K. Jha, X. L. Duncan and X. Jia, Biomaterials, 2011, 32, 2466. 47. B. Ananthanarayanan, Y. Kim and S. Kumar, Biomaterials, 2011, 32, 7913. 48. S. Hong, K. Yang, B. Kang, C. Lee, I-T. Song, E. Byun, K-I. Park, S-W. Cho and H. Lee, Advanced Functional Materials, 2013, 23, 1774. 49. J.
The constructs led to the production of an elastic, firm, and translucent cartilage with zonal architecture within a rabbit defect model [51]. Similarly, the 2:2:1 HA:gelatin:PEG with human ESC produced hyaline-like neocartilage that had good surface regularity and complete integration with adjacent tissue in vivo in critical sized osteochondral defects in rats. 4) [73]. In another example, a 3D in vitro system, incorporating PEG diacrylate along with HA, CS, and a matrix metalloproteinase (MMP) sensitive peptide, was developed that produced zonal tissue similar to articular cartilage from encapsulated mouse bone marrow MSC [74].