By B.-M. Uebele-Kallhardt
The final decade has obvious impressive advances in human ge netics. as soon as the right kind chromosome variety of the human genome was once ascertained, a wide selection of ailments was once rec ognized as as a result of numerical chromosome anomalies. There the invention that spontaneous abortions are the results of chromosome blunders, and particular band styles of chromosomes allowed id of minute lesions. The strategies of mobile hybridization now permit particular gene assign ment to chromosomes or even to unique loci on their palms. All this used to be attainable a result of ease with which metaphase chromosomes may be received and manipulated. The a lot older means of research of meiotic chromosomes has taken a again seat during this fascinating period. Being less without difficulty accessi ble, spermatogonial research is far much less usually below taken and is much less profitable. much more tough for research is the feminine meiotic method. not just is meiosis extraordinar ily lengthy, spanning from earlier than start to ovulation, the tech niques for its examine and the persistence required for specified inquiry were major hindrances. whilst, the suspicion that lady meiotic research aren't basically be worthwhile yet that it can be needed has been with us ever because it used to be well-known optimistic correlation exists among chromosomal nondisjunction and maternal age. ahead of the intricacies of chromosomal habit which are re sponsible for nondisjunction are understood, even if, it will be important that we understand the normalcy of the process.
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Additional resources for Human Oocytes and Their Chromosomes: An Atlas
Example text
Cambridge: Cambridge Univ. Press 1972. : A quantitative and cytological study of germ cells in human ovaries. Proc. R. Soc. Lond (BioI) 158, 417-433 (1963). : The structure of the chromosomes in human primordial oocytes. Chromosoma 22, 358-377 (1967). W. ): Oogenesis. Baltimore: University Park Press; London: Butterworths 1972. : Observations on living oogonia and oocytes from human embryonic and fetal ovaries. Am. J. Obstet. Gynecol. 104/3, 310-319 (1969). : Specific gene amplification in oocytes.
104/3, 310-319 (1969). : Specific gene amplification in oocytes. Science 160, 272-280 (1968). : The Nucleolus. New York-London: Academic Press 1970. : Biochemical activities of chromosomes during the prophase of meiosis. In: Handbook of Molecular Cytology, Lima de Faria, A. ). , 1969, pp. 540-553. : DNA and Chromosomes. New York-London: Holt, Rinehart and Winston 1970. : Die Chromosomenstruktur des Menschen in Mitosis und Meiosis. Fortschritte der Evolutionsforschung, Heberer G. ) Stuttgart: G.
J. Obstet. Gynecol. 104/3, 310-319 (1969). : Specific gene amplification in oocytes. Science 160, 272-280 (1968). : The Nucleolus. New York-London: Academic Press 1970. : Biochemical activities of chromosomes during the prophase of meiosis. In: Handbook of Molecular Cytology, Lima de Faria, A. ). , 1969, pp. 540-553. : DNA and Chromosomes. New York-London: Holt, Rinehart and Winston 1970. : Die Chromosomenstruktur des Menschen in Mitosis und Meiosis. Fortschritte der Evolutionsforschung, Heberer G.