By Stacey E Mills MD
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Extra resources for Histology for pathologists
Sample text
Apoptosis Apoptosis, or programmed cell death, is the mechanism by which cells are deleted in normal tissue (3 3) and is the process responsible in establishing the final normal architecture of adult skin (3 4) . Terminal differentiation of the epidermis into a stratified squamous layer can be considered a specialized form of apoptosis (3 4) . Apoptosis also participates in the cycling of the hair follicle (3 5,3 6,3 7) and is the principal mechanism by which catagen hair is formed (3 8,3 9,4 0).
The sublamina densa zone, or pars fibroreticularis, contains mainly the anchoring fibrils (7 4) (type VII collagen) that attach the basal lamina to the connective tissue of the dermis. Antibodies against epidermolysis bullosa aquisita react with the carboxy terminus of type VII collagen (7 5,7 6) . , bullous pemphigoid). Melanocytes Melanocytes are dendritic cells that derive from the neural crest. During migration from the neural crest, melanocytes may localize in other epithelia. In the epidermis, the melanocytes are localized in the basal layer, and their dendritic processes extend in all directions.
17), and the Demodex folliculorum (Figure infundibulum. 16 Hair follicle showing the hair shaft (center) surrounded by the inner root sheath, which contains trichohyalin granules. The outer root sheath is composed of clear cells. 17 Yeasts of Pityrosporum in the follicular infundibulum. The mantle hair of Pinkus (103) is a hair follicle in which proliferation of basaloid epithelioid cells emanating from the infundibulum is seen. 19). The significance of this hair follicle is not known. The hair growth is in lifelong cyclic transformation.