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Their advantage over DNase I was their virtual lack of DNA sequence specificity, which allowed the cleavage periodicity to be obtained with nucleosomes reconstituted at specific locations of unique DNA fragments, in contrast with DNase I which would cleave only some of the potential sites. 7 bp/turn periodicity in the $ 30 bp central region [24]. Because the same average cleavage periodicity and discrepancy in the center were found with mixed-sequence nucleosomes, it was proposed that OH radicals cleaved all nucleosomes in the same way [25].
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Note that axes of motion appear parallel and in plane with the pitch of the DNA. In this view the ventral surface is on the bottom of the image. 39 and displays a lateral component. It would appear that the composite libration for the H3 : H4 dimers cancel each other in the direction of the dyad axis. Instead, the primary axis of motion runs towards the 146–147 bp end of the DNA. What results in the cancellation of motion in the direction of the dyad is unclear. One possible explanation is that the two H3 : H4 dimers synchronously oscillate in opposite directions so that the net motion for the paired dimers is cancelled.