By J M McPartland; Robert Connell Clarke; David Paul Watson
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34. Malekar P, Hagenmueller M, Anyanwu A, et al. Wnt signaling is critical for maladaptive cardiac hypertrophy and accelerates myocardial remodeling. Hypertension. 2010;55:939–45. 35. Martin J, Afouda BA, Hoppler S. Wnt/beta-catenin signalling regulates cardiomyogenesis via GATA transcription factors. J Anat. 2010;216:92–107. 36. Iacobas DA, Iacobas S, Urban-Maldonado M, et al. Similar transcriptomic alterations in Cx43 knock-down and knock-out astrocytes. Cell Commun Adhes. 2008;15:195–206. 2 Effects of Chronic Intermittent Hypoxia on Cardiac Rhythm Transcriptomic Networks 37.
Correspondingly, certain very unstably expressed genes may be involved in the adaptation to environmental changes. Thus, the analysis of expression variability may provide valuable indication with regard to the role of various genes in maintaining the function or ensuring adaptation of the system to the environment changes. Remarkably, genes such as Smyd1, Eef2, and Lyn were switched between stably and very unstably expressed, indicating profound reconfiguration of transcription control priorities.
Mechanisms of human arrhythmia syndromes: abnormal cardiac macromolecular interactions. Physiology (Bethesda). 2007;22:342–50. 9. Dostanic I, Schultz Jel J, Lorenz JN, et al. The alpha 1 isoform of Na, K-ATPase regulates cardiac contractility and functionally interacts and co-localizes with the Na/Ca exchanger in heart. J Biol Chem. 2004;279:54053–61. 10. Lee RS, Lam CW, Lai CK, et al. Carnitine-acylcarnitine translocase deficiency in three neonates presenting with rapid deterioration and cardiac arrest.