By Zhi-Jie Liu, John Hempel, Julie Sun (auth.), Henry Weiner, Ronald Lindahl, David W. Crabb, T. Geoffrey Flynn (eds.)
Since 1982, our ever-expanding team of investigators has been assembly in unique components of the area to debate elements of 3 enzyme platforms. The 1996 assembly used to be no exception. approximately ninety scientists from 15 international locations met within the small urban of Deadwood, South Dakota, for 4 days of stimulating talks and posters and tremendous surroundings. once again this assembly mirrored the altering traits in biochemical study. on the 1982 assembly lots of the audio system mentioned separating new enzymes and attempting to signify them. At this assembly many audio system mentioned interpretations of third-dimensional struc ture or regulatory parts of the genes controlling for the tissue-specific expression of the enzyme. optimistically, readers will locate the court cases of the assembly to be of curiosity. even though they displays the clinical info that was once provided on the assembly, they don't point out the extent of non-public interactions that went on throughout the assembly. once more, the willingness of the individuals to debate unpublished facts and to percentage strategies in regards to the destiny instructions in their study helped make this, like our prior seven conferences, a different clinical event if you happen to attended.
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Extra info for Enzymology and Molecular Biology of Carbonyl Metabolism 6
Sample text
1996) is the induction of P4501Al. Multiple functional XREs have been identified in the 5 '-upstream regulatory region of the CYPIAI gene. , 1990; Favreau and Pickett, 1991). ,1994). , 1990). , 1995). While evidence exists for negative regulation of other genes in the Ah gene battery, no studies have provided mechanistic details for the ALDH-3 gene. , 1993), since phosphorylation of proteins acting at some step in transactivation by the AhR was shown to apparently be dependent upon protein kinase C (PKC) activity.
The Ah receptor-ligand complex is translocated into the nucleus after ligand activation and forms a heterodimeric complex with the arylhydrocarbon nuclear transporter protein (ARNT); subsequently they interact with specific DNA sequences denoted xenobiotic responsive elements (XREs) to increase the transcription of these genes. AhR mediates induction of a number of xenobiotic metabolizing enzymes (termed the Ah gene battery), including cytochromes P4501A/B, glutathione S-transferase Yal' NAD(P)H:quinone oxidoreductase, UDP-glucuronosyl transferase I *6 and Class 3 aldeEnzymology and Molecular Biology of Carbonyl Metabolism 6 edited by Weiner et al.
0 ED CON DEX BA BA+OEX Treatment Figure 1. Effect of Dexamethasone on PAH-induction of P4501 A I and ALDH-3 enzyme activity in cultured rat hepatocytes. Adult rat hepatocytes were prepared as described by Xiao el al. (1995) and treated with either DMSO (CON), I ~M dexamethasone (DEX), 50 ~M 1,2-benzanthracene (BA). or a combination of these agents (BA+DEX). The cell protein was harvested after 2-3 days and the enzyme acti vity measured for three pooled sets of cells. D. D. for ALDH-3. 32 R. A. Prough et al.