By Ivan Dikic

Endosomes are a heterogeneous inhabitants of endocytic vesicles and tubules that experience captivated the curiosity of biologists for a few years, partially as a result of their vital mobile services and in part because of their fascinating nature and dynamics. Endosomes characterize a desirable interconnected community of hundreds of thousands of vesicles that delivery a number of cargoes, frequently proteins and lipids, to far away mobile locations. How endosomes functionality, what co-ordinates the molecular determinants at every one step in their dynamic existence cycle and what their organic and scientific relevance is, are one of the questions addressed during this book.

Show description

Read Online or Download Endosomes PDF

Best biology books

The Biology of Biodiversity

Organic range, or biodiversity, refers back to the common characteristic of all residing organisms that every person being is exclusive - that's, no organisms are exact. The biology of biodiversity needs to contain all of the features of evolutionary and ecological sciences examining the starting place, adjustments, and upkeep of the di­ versity of residing organisms.

The Prokaryotes: Prokaryotic Biology and Symbiotic Associations

The Prokaryotes is a entire, multi-authored, peer reviewed reference paintings on micro organism and Achaea. This fourth version of The Prokaryotes is prepared to hide all taxonomic range, utilizing the kinfolk point to delineate chapters. assorted from different assets, this new Springer product comprises not just taxonomy, but additionally prokaryotic biology and expertise of taxa in a extensive context.

Oxford Handbook of Dialysis

The Oxford instruction manual of Dialysis is a finished and sensible advisor to all features of dialysis, the administration of sufferers with finish level kidney affliction, and all its issues. The fourth variation has been thoroughly up to date, and covers all points of dialysis from haemodialysis concepts and haemodiafitration, to the scientific, nursing and psychosocial facets of coping with sufferers with finish degree kidney failure.

Biotherapeutic Approaches to Asthma Biotherapeutic Approaches to Asthma

Illustrates advanced interactions inside mucosa and the airway wall to big organic pathways and bring new therapeutics within the administration of allergic issues. summary: Illustrates complicated interactions inside of mucosa and the airway wall to special organic pathways and bring new therapeutics within the administration of allergic problems

Extra info for Endosomes

Example text

J Biol Chem 2002; 277:12190-12199. 97. Stein M P , Feng Y, Cooper KL et al. H u m a n VPS34 and p i 5 0 are Rab7 interacting partners. Traffic 2003; 4:754-771. 98. Ortiz D , Medkova M, Walch-Solimena C et al. Ypt32 recruits the Sec4p guanine nucleotide exchange factor, Sec2p, to secretory vesicles; evidence for a Rab cascade in yeast. J Cell Biol 2002; 157:1005-1015. 99. Walch-Solimena C, Collins RN, Novick P. Sec2 mediates nucleotide exchange on Sec4 and is involved in polarized delivery of post-Golgi vesicles.

Further studies of small GTPases and their effectors will be pivotal for our understanding of how membrane compartmentalization into domains may specify the identity and function of intracellular organelles. Acknowledgements The work in Marino Zerial s laboratory was supported by grants from the HFSP (RG-0260/ 1999-M), the European Union (HPRN-CT-2000-00081) and die Max Planck Society. References 1. McMahon HT, Mills IG. COP and clathrin-coated vesicle budding: Different pathways, common approaches.

Stenmark H , Parton RG, Steele-Mortimer O et al. Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis. E M B O J 1994; 13:1287-1296. 39. Barbieri MA, Li G, Colombo M et al. Rab5, and early acting endosomal GTPase, supports in vitro endosome fusion without G T P hydrolysis. J Biol Chem 1994; 269:18720-18722. 40. Wucherpfennig T , Wilsch-Brauninger M, Gonzalez-Gaitan M . Role of Drosophila Rab5 during endosomal trafficking at the synapse and evoked neurotransmitter release.

Download PDF sample

Download Endosomes by Ivan Dikic PDF
Rated 4.88 of 5 – based on 9 votes