By Ralph Lazzara MD (auth.), Ihor Gussak, Charles Antzelevitch (eds.)
Electrical illness of the guts, 2d variation, quantity 1, presents a useful perception to the most recent advancements within the box of cardiac electrophysiology and scientific electrocardiology. each one bankruptcy contains up to date result of reports geared toward offering an knowing of functionality of the guts in wellbeing and fitness and affliction, demonstrated and evidence-based wisdom of medical results, parts of controversy, and destiny tendencies. This publication is extremely proper to a huge viewers, starting from scientific and graduate scholars, to clinicians and scientists.
Read Online or Download Electrical Diseases of the Heart: Volume 1: Basic Foundations and Primary Electrical Diseases PDF
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Extra resources for Electrical Diseases of the Heart: Volume 1: Basic Foundations and Primary Electrical Diseases
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2002;282:H516–30. 89. Decker KF, Heijman J, Silva JR, Hund TJ, Rudy Y. Properties and ionic mechanisms of action potential adaptation, restitution, and accommodation in canine epicardium. Am J Physiol Heart Circ Physiol. 2009;296:H1017–26. 90. Nygren A, Fiset C, Firek L, Clark JW, Lindblad DS, Clark RB, et al. Mathematical model of an adult human atrial cell: the role of K+ currents in repolarization. Circ Res. 1998;82:63–81. 91. Courtemanche M, Ramirez RJ, Nattel S. Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model.
Recently, the development of efficient nonviral transfection technology has allowed heterologous expression of foreign cDNA in neonatal (if not adult) cardiomyocytes with much less delay than methods using viruses as transfecting agents [79]. This has provided a versatile new model for the studies of WT or mutated ion channel-related protein function in a cardiomyocyte subcellular environment. In parallel, synthetic short interfering RNAs (siRNAs or antagomirs) designed to target endogenous mRNAs, as miRs, have been developed.
Dominant pacemaker activity is always located in the newly formed 3. Developmental Aspects of the Electrophysiology of the Heart: Function Follows Form myocardium at the venous pole [21, 22]. This generates a unidirectional blood flow from the venous to the arterial pole. While the ventricular and atrial chamber myocardium differentiates and rapidly proliferates at specific sites within the heart tube, the remainder of the myocardium maintains the primary phenotype.
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