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Bioinformatics 15(3): 187–193. , Trifonov, E. N. & Bolshoy, A. (2004). Sequence periodicity of Escherichia coli is concentrated in intergenic regions, BMC Molecular Biology 5(1): 14. com/1471-2199/5/14 Ito, T. (2007). Role of histone modification in chromatin dynamics, Journal of Biochemistry 141(5): 609–614. Jenuwein, T. & Allis, C. D. (2001). Translating the histone code, Science 293(5532): 1074–1080. 26 24 DNA Methylation – From GenomicsWill-be-set-by-IN-TECH to Technology Jung, I. & Kim, D.

Early attempts at computational methods and models dealing with (i) association of DNA sequences and DM, and (ii) Interdependencies between DM and HM have been explained in detail. Further, we propose approaches to analyse the two elements such as DNA sequence patterns and HM evolution and their influence over DNA methylation mechanisms. Finally, evaluation of success achieved through such computational attempts is illustrated briefly in our results section. The application of Fourier techniques helped to understand how the sequence patterns appear within the genome and also postulate their control over DM.

Kavanagh, E. & Joseph, B. (2011). Histone Onco – Modifications, Oncogene 30(31): 3391–3403. 121 Gao, F. -T. (2006). GC-Profile: a web-based tool for visualizing and analyzing the variation of GC content in genomic sequences, Nucleic Acids Research 34(2): 686–691. , Varley, K. , Reddy, T. , Bowling, K. M. & Pauli, F. (2011). Analysis of DNA methylation in a three-generation family reveals widespread genetic influence on epigenetic regulation, PLoS Genetics 7(8): e1002228. Glass, J. , Fazzari, M. , Ferguson-Smith, A.

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