By Tally Naveh-Many PhD, Morris Nechama PhD (auth.), Angelo A. Licata, Edgar V. Lerma (eds.)
For practitioners in any respect levels of expertise, illnesses of the parathyroid glands are usually not simply deciphered. there are numerous subtleties to its pathology and analysis. this present day, the wealth of recent info from molecular drugs makes it very tough for the person practitioner to have a whole photo of those entities. Diseases of the Parathyroid Glands addresses those concerns through delivering a concise, uncomplicated textual content that gives cutting-edge heritage on mineral body structure and its legislation and this to a number of medical subject matters of parathyroid gland pathology. Introductory chapters hide calcium law and parathyroid gland body structure, drawing upon a number of the new elements of glandular keep an eye on mechanisms past the classical ones linked to calcium by myself. nearly all of the textual content covers scientific difficulties. even though such a lot chapters tackle difficulties in grownup drugs, 3 separate chapters are dedicated to pediatric difficulties of hyper- and hypoparathyroidsm and parathormone resistance states. moreover, there are a number of chapters on much less universal yet both not easy difficulties similar to parathyroid melanoma, calciphylaxis, cystic lesions of the glands, and ectopic glandular ailment. the ultimate chapters aspect the options of parathyroid gland imaging and surgical operation. useful and a useful addition to the literature, Diseases of the Parathyroid Glands is an crucial reference for someone drawn to parathyroid disease.
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Extra info for Diseases of the Parathyroid Glands
Sample text
1 Partial structure of the bone mineral hydroxyapatite. A view of the repeating structural unit of hydroxyapatite based on the analysis in [269]. The corners of the effectiveness with which calcium and phosphate are released from ingested food. They also depend on the efficiencies of intestinal absorption, glomerular filtration, and renal tubular reabsorption along with rates of transfer between the blood and the bone mineral store as well as the magnitudes of unavoidable losses associated, for example, with small and large intestinal secretions.
In this chapter, the author considers the biological processes that underlie the balances of Ca2+ and phosphate as well as the key points of exchange in the gut, kidney, and bone, together with their regulation. These balances depend on dietary composition and the Fig. 1 Partial structure of the bone mineral hydroxyapatite. A view of the repeating structural unit of hydroxyapatite based on the analysis in [269]. The corners of the effectiveness with which calcium and phosphate are released from ingested food.
2). In consequence, the overall balances for calcium and phosphate are determined by the rates of intestinal absorption and secretion, the rates of renal filtration and reabsorption, the rates of uptake and extrusion from the cytoplasmic compartment of all tissues, and the rates of bone mineralization and resorption. While the rates of calcium and phosphate uptake and release from bone mineral are matched by the structure of the repeating unit of hydroxyapatite, (Ca10(PO4)6(OH)2), in which the relative proportion of Ca:phosphate is 5:3, the rates of calcium and phosphate transfers between the extracellular fluid and other compartments are less predictable and regulated independently.