By David J. Dabbs
Diagnostic Immunohistochemistry provides the newest info and greatest assistance on immunohistological diagnoses in surgical pathology. David J. Dabbs, MD and different major specialists carry you cutting-edge assurance on genomic and theranostic functions, molecular anatomic pathology, immunocytology, Non-Hodgkin's lymphoma, and extra. extra positive factors reminiscent of tables discussing antibody standards, differential analysis containers, ancillary anatomic molecular diagnostics, and full-color histological photos be sure easy assurance that makes key info effortless to discover and follow. The absolutely searchable textual content can be to be had on-line at expertconsult.com, besides a downloadable picture financial institution and entry to direction seek advice. This concise and entire source is contemporary vital consultant to the powerful use of immunohistochemical analysis. Discusses diagnostic pitfalls via immunohistologic differential prognosis anyplace applicable so that you provides the main exact diagnoses. provides chapters prepared by way of organ approach for accomplished insurance of all proper info in a handy and intuitive association. offers quickly reference graphs for antibodies in the course of the textual content that illustrate the frequency of immunostaining for numerous antibodies in tumors. contains Key Diagnostic issues containers in each bankruptcy for a fast precis of textual content parts which are of specific value. gains knowledgeable writer for every bankruptcy to make sure insurance of the present cutting-edge. comprises entry to the whole textual content on-line at expertconsult.com, in addition to a downloadable snapshot financial institution and direction seek advice. presents information at the position of genomics in deciding upon genetic and molecular elements of sickness which can impact sufferer care and healing techniques. Covers theranostic purposes to help you evaluation healing offerings in line with immunohistochemical effects. displays the newest advancements within the box via new chapters on molecular anatomic pathology and immunocytology, in addition to up to date chapters on immunohistology of the prostate, bladder, testis, and kidney and Non-Hodgkin's lymphoma. Discusses antibody standards with tables that express details on makes use of, clones, owners, resources, antibody titers, and kinds of antigen retrieval. provides key differential diagnoses containers that supply tabular summaries of DDx and algorithms. positive aspects discussions of ancillary anatomic molecular diagnostics as an accessory to immunohistochemistry for a extra well-rounded diagnostic method. thoroughly interpret immunohistochemical effects and supply the clinician with the simplest healing ways for the patientYour buy entitles you to entry the website until eventually the subsequent variation is released, or till the present variation is not any longer provided on the market through Elsevier, whichever happens first. Elsevier reserves the correct to supply an appropriate alternative product (such as a downloadable or CD-ROM-based digital model) should still entry to the website be discontinued.
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Extra info for Diagnostic Immunohistochemistry: Theranostic and Genomic Applications, Third Edition
Example text
Other than errors introduced by personnel or machine malfunction, the influence of processing on immunostaining results has not been studied thoroughly. One of the few problems in this area that has been described is due to inadequate tissue dehydration before paraffin embedding. This problem can be reduced by preparing fresh alcohol solutions on a more frequent and regular basis. Other processing problems include the use of incorrect slides, which can result in loss of tissue adherence. Imprecise sectioning can cause crinkling or folding of the tissue, which may result in reagent trapping and uneven staining patterns.
As described, open automated systems, in contrast, are more flexible and allow for the use of other reagents and protocols. These protocols can be customized and stored for use at any time. Each laboratory should make this decision TECHNIQUES, PROTOCOLS, AND “TROUBLESHOOTING” carefully when choosing an option for an instrument. It is like purchasing a car—the technician is “selling” it to you and will present the instrument to its advantage. The application of automation for immunostaining offers several advantages.
It cannot replace a pathologist’s expertise when selecting the appropriate tests to be performed or when interpreting tissue sections. It is, therefore, by no means a panacea for laboratories with poor quality control standards. Only a laboratory with high standards and proper controls can operate an automated machine effectively. However, automation can and does provide reproducible, standardized, and uniform results and serves as a prelude to quantitative IHC and computerized image analysis. It is time for the morphology and immunochemistry of tissue diagnosis to unite, not only for diagnosis but also for prognosis and therapy.