By Anne Freimann
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JAMA 1940; 114: 480–4. 37 Merritt HH, Putnam TJ. Experimental determination of anticonvulsive activity of chemical compounds. Epilepsia 1945; 5 (Series 11): 51–75. PREFACE 38 Goodman LS, Toman JEP, Swinyard EA. Anticonvulsant drugs; mechanisms of action and methods of assay. Arch Int Pharmacodyn Ther 1949; 78: 144–62. 39 Swinyard EA. Laboratory assay of clinically effective antiepileptic drugs. J Am Pharm Assoc 1949; 38: 201–4. 40 Swinyard EA, Brown WC, Goodman LS. Comparative assays of antiepileptic drugs in mice and rats.
Clonic seizures Fast activity (10 c/s or more) and slow waves; occasional spike-and-wave patterns Spike-and-wave or polyspike-andwave discharges D. Tonic seizures Low voltage, fast activity or a fast rhythm of 9–10 c/s or more decreasing in frequency and increasing in amplitude More or less rhythmic discharges of sharp and slow waves, sometimes asymmetrical. Background is often abnormal for age E. Tonic-clonic seizures Rhythm at 10 or more c/s decreasing in frequency and increasing in amplitude during tonic phase, interrupted by slow waves during clonic phase Polyspike and waves or spike-andwave, or, sometimes, sharp-andslow-wave discharges F.
Boston: Little, Brown, 1960. 2 Lennox W. Progress in the study of epilepsy in America in 1937. Epilepsia 1939; 196–208. 3 Kinnear Wilson SA. Neurology. London: Edward Arnold, 1940. 4 Cobb S, Cohen ME, Ney J. Brilliant Vital Red as an anticonvulsant. Arch Neurol Psychiatr 1938; 37: 463–5. 5 Lennox W. Study of epilepsy in America in 1938. Epilepsia 1940; 279– 90. 6 Aird RB. Mode of action of brilliant vital red in epilepsy. Arch Neurol Psychiatr 1939; 42: 700–23. 7 Cohen B, Myerson A. Effective use of phenobarbital and benzedrine sulphate (amphetamine sulphate) in treatment of epilepsy.