By B. Glasmacher-Seiler, J. Jonas, G. Schädlich, H. Reul, G. Rau (auth.), Dr. Ing. Heinrich Planck, Dipl.-Ing. Martin Dauner, Dipl. Biol. Monika Renardy (eds.)

Tradi tionally, the foreign lTV - meetings on Biomate­ rials are focussing on difficulties in Biomedical Engineering, difficulties, that are nonetheless unsolved, of major curiosity, and that are of interdisciplinary personality. In 1983, the department of Biomedical Engineering of the Institute of cloth expertise and Chemical Engineering, Denkendorf, all started wi th a convention in regards to the use of polyurethanes in biomedicine. 3 years later,. in 1986, development in improvement and use of polyurethanes used to be chosen as convention subject. It needed to be discovered that degradation difficulties have been nonetheless dominating the discussions. the most dialogue subject matters have been: What are the explanations for the degradation? How can one hinder them? What are the degradation items, and do they impact the human physique? How can one simu­ past due the degradation? How can one speed up the in vitro exams and the way can the implications are expecting the in vivo behaviour of the fabric? How do in vitro checks correlate with animal assessments and the behaviour within the human physique? on the 3rd convention in 1989, the audio system eager about using textiles in drugs. back the matter of decay used to be mentioned intensively and proven via the failure of fabric implants, the degradation of aramide polymers or the degradation of resorbable suture fabrics. The examples clarify, that degradation could be a wanted or undesired estate of an implant.

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4 In infected sites, hoerver, degradation was accelerated exponentially to produce complete loss of physical properties within a few months. 8. In our own experience we have had several incidences where abandoned cardiac pacemaker leads were accused of provoking a proliferative fibrous response at their subcutaneously buried proximal ends. Examination of the excised tissues, however, revealed fragments of fibers from a PET fabric (Parsonnet pouch) which had been used to provide fixation for the pulse generator.

Springer-Verlag Berlin Heidelberg 1992 38 AROMATIC POLYESTER Polyethylene terephthalate (PET) woven or knitted fabrics are widely use in large caliber vascular grafts, tissue fixation, etc. be good, but not sewing rings for cardiac valves, AV shunts, In general, the experience with PET fabrics appears to entirely trouble- free. In one 1 example, a PET femoro- popliteal vascular graft developed aneurysm after 84 months implant, and was removed. Physico-chemical analysis of the material showed that dilitation had taken place subsequent to hydrolytic degradation of the fibers.

Zaikof GE (1985) JMS-Rev, Macromol Chem Phys C25(4): 551-597 5. Kopecek J and Ulbrich K (1983) Prog Polym Sci 9: 1-58 6. MCClellan KA and Billson FA (1991) Ophthalmic surg 22 (2) :74-77 7. Hayasaka S, Ishiguro SI, Ophthalmol 93(1) :111-117 8. Hudson JA and Crugnola A 1987) J Biomater Appl 1(4):487-501 9. Teoh SH, Martin 36(3):417-421 10. Vondracek P and Dolzel B (1984) Biomaterials 5:209-214 11. The Pacemaker Telectronics Bulletin for the Cardiac Pacemaker Clinic. Telectronics, USA, January 1972, p7 12.

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