By Sabine Globig, William Hunter Jr.
Pharmaceutical expertise offers with the invention, creation, processing, and secure and powerful supply of medicines to sufferers. applied sciences concerned comprise machine modeling for study, bioengineering for examine instrumentation, approaches and techniques for expanding construction, and computing know-how and biosystematics for the administration and research of information. This new publication covers a variety of vital themes on modern day pharmaceutical expertise, resembling in vitro drug liberate and regulated drug supply, using nanotechnology in prescription drugs, quantum dot imaging, asse. Read more...
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Mice were sacrificed on day 21. Tumor size was measured by calipers (length and width) every 3 days. The tumor volume (V = 1/2 length × width2) was calculated and the tumor growth curve was generated (y = A e kt). The tumor doubling time (T = ln2/K, k: growth rate) and inhibition rate on day 21 were calculated. The inhibition rate was calculated as follows: (1-the volume change of experiment group/the volume change of control group) × 100%. The establishment, grouping, and treatment protocol of the Tca8113 cell xenograft (oral squamous cell carcinoma) was similar to the Lovo cell xenograft, except for the following differences: (1) treatment began on day 8, (2) the drug was injected every 2 days for 8 times (16 days), and (3) the mice were sacrificed on day 34.
The authors thank Dr. -C. Lin for assistance in development of the antiviral assays. COMPETING INTERESTS The author(s) declare that they have no competing interests. Chapter 3 Hydroxycamptothecin-loaded Nanoparticles to Enhance Drug Delivery Anxun Wang and Su Li INTRODUCTION Hydroxycamptothecin (HCPT) has been shown to have activity against a broad spectrum of cancers. In order to enhance its tissue-specific delivery and anti-cancer activity, we prepared HCPT-loaded nanoparticles made from poly(ethylene glycol)poly(γ-benzyl-L-glutamate) (PEG-PBLG), and then studied their release characteristics, pharmacokinetic characteristics, and anti-cancer effects.
CK-Tat9 would enhance the pharmacological properties in vivo for more effective delivery. CK-Tat9 to plasma proteins and rapid elimination from the blood (Foroutan and Watson, 1999). CK-Tat9, which could result higher in vivo activity. CK(biotin)-Tat9 in cell culture experiments (Table 1). CK(biotin)-Tat9 and PEG were very stable, insuring that Tat was not released from the conjugate. CK-Tat9 depends upon its release from PEG, presumably reflecting a requirement for entry into infected cells. , 1997).