By Baldev K. Vig (auth.), Baldev K. Vig (eds.)

Aneuploidy - the best genetic disease of guy - has its foundation in manycellular procedures. Its forerunner, chromosome non-disjunction, may result from malfunction of 1 of many techniques thinking about devoted segregation of chromosomes in the course of mitosis or meiosis. specialists on chromosome biology,centromere, kinetochore, microtubules, spindle gear, biochemistry of mitosis and meiosis, developmental biology, and environmental mutagenesis talk about easy and utilized elements of the way chromosomes malsegregate and the way aneuplody originates. the latest suggestions hired to check chromosome segregation and likewise the right way to make sure aneugenic chemical compounds are defined.

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Extra resources for Chromosome Segregation and Aneuploidy

Sample text

This corresponds fairly well with the position of the internucleosome linker determined by nucleosome mapping experiments in African green monkey, where a significant proportion of nucleosomes are phased with respect to the underlying sequence(Simpson, 1990). If CENP-B 20 does indeed bind in the linker region, its acidic domains may be available for interactions with histones (perhaps CENP-A). , 1992). Unlike CENP-B, the deduced amino acid sequence of CENP-C suggests no obvious domain structure.

Finally, the absence of kinetochores in these same cells suggests that the kinetochore is necessary for prometaphase movement. 22 These studies were limited in their conclusions about the roles of individual CENPs, since the ACAs injected recognized more than one CENP. Recently, we have injected cells with rabbit polyclonal antibodies specific to CENP-C (1. A. Cooke, H. Saitoh, R. L. C. Earnshaw, unpublished). These cells transiently arrest at metaphase, and ultrastructural examination reveals that kinetochores are disrupted in the presence of microtubules.

4B) (Yoda et ai, 1992). col; also formed complex A. N16 B ++ ++ ++ ++ B~ 1 926 . 'ZZZI 599 rzLZZZZZ

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