By Monique Dubois-Dalcq, Regina Armstrong, Bryn Watkins, Randall McKinnon (auth.), Gunnar Jeserich, Hans H. Althaus, Thomas V. Waehneldt (eds.)
Specialists within the box of mobile and molecular biology of myelination current their newest effects. a variety of thoughts have been used resembling tissue tradition, transplantation, transfection, immunocytochemistry and methods to check the phylogenetic facets of myelination in addition to molec- ular biology. bearing on glial cells: hormones and moment messengers play a huge function within the legislation of the phenotype and the expression of myelin parts on the transcriptional point; those findings also are a part of specific relevance for remyelination. pertaining to myelin: compositional stories published progressively more minor parts to be of an important value for mobile adhesion strategies; from a phylogenetic perspective vertebrate myelin has existed for four hundred million years with vital changes in its compositon. This e-book bargains an excellent choice of the newest effects offered by means of the world over reknowned scientists.
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Extra resources for Cellular and Molecular Biology of Myelination
These two properties of the myelin sheath, explain the importance of the integrity of the myelin sheath. Biochemical Composition and Metabolism of the Oligodendrocyte The existing morphological evidence of the connection between the oligodendrocyte and the myelin sheath suggests that a main part of the metabolic activity of these cells is oriented towards the synthesis of myelin components. , 1982). The lack of space prevents us from describing the lipids and proteins present in myelin. (For review see Norton, 1984; Espinosa, 1987).
L. Gard, A. E. Warrington Department of Microbiology and Program in Neurological Sciences University of Connecticut Health Center Farmington, CT 06032 USA INTRODUCTION The differentiation of oligodendrocytes (Ol) and their elaboration of myelin sheaths is a crucial event of brain development. The resultant saltatory nerve conduction allows for dramatic savings in energy consumption and space utilization. Disruption of myelinogenesis causes serious neurological deficits, many with chronic implications (Morell, 1984).
R-mAb reacted with galactocerebroside, monogalactosyldiglyceride, sulfatide, seminolipid, and psychosine. We found by several assay methods that RmAb reacts nearly as well with sulfatide, indicating that it cannot be used as an unequivocal marker for GalCer, and that sulfatide reactivity may contribute to the staining of oligodendrocyte surfaces. 01 reacted with galactocerebroside, monogalactosyldiglyceride and psychosine, and in addition labeled an unidentified species in rat brain extracts. Among the three antibodies tested, 01 would appear to be the choice for identifying the appearance of GalCer on the surfaces of developing oligodendrocytes.
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