By Robin G. Shanks (eds.)
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Am. J. , 203, 122-124. E. M. (1977). Blood flow measurements with radionuclide-labelled particles. Prog. Cardiovasc. , 20,55-79. B. (1968). Regional venous drainage of the human heart. Br. , 30, 105-109. W. J. (1974). Effect of isoproterenol on coronary blood flow in primary myocardial disease. Circulation, 50, 560-564. , KATORI, R. (1972). Measurement of coronary sinus blood flow by dye dilution technique in man. J. lab. c/in. , 79,75-81. , MURAGUCHI, I. & HAYASHI, T. (1976). Coronary blood flow and lactate metabolism during isometric hand-grip exercise.
The conversion from mean forward velocity to flow requires an accurate measurement of cross sectional area of the coronary artery at the point of the catheter tip. In man at cardiac catheter this can only be done by measurements from coronary angiography in more than one plane using a grid system (Vieweg, Alpert & Hagan, 1976). The known diameter of the cardiac catheter is used as a standard to assess magnification. Benchimol et al. (1971) observed a 10-15% increase in coronary velocity in both systolic and diastolic fractions following nitroglycerine administration.
The weight is unknown and by substituting 100 for Wt then flow is expressed in ml min-I 100 g-I muscle. , 1962) calculated in dogs and assumed to be the same in man. The method assumes arterial inflow to equal venous outflow, that myocardial gas and venous gas are in equilibrium, and that radioactivity only leaves the heart by venous 34 drainage. 133Xenon has a shorter half life than 85Krypton and with a lower energy emission make it a more suitable isotope: both from the aspect of radiation hazard, and the speed with which the study can be repeated.