By Joseph A. Vinson

content material: A survey of metabolic adjustments of [delta]¹-tetrahydrocannabinol / Sumner Burstein --
GLC and HPLC analyses of cannabinoids in organic fluids and purposes / E.R. Garrett, A.J. Gouyette, and C.A. Hunt --
Detection and quantitation of tetrahydrocannabinol in physiological fluids / Monroe E. Wall, Dolores R. Brine, Joan T. Bursey, and David Rosenthal --
Quantitation of [delta]⁹-tetrahydrocannabinol and 11-nor-[delta]⁹-tetrahydrocannabinol-9-carboxylic acid in physique fluids via GC/CI-MS / R.L. Foltz, P.A. Clarke, B.J. Hidy, D.C.K. Lin, A.P. Graffeo, and B.A. Petersen --
development of the mass fragmentographic procedure for quantification of tetrahydrocannabinol in human blood plasma / Agneta Ohlsson, Stig Agurell, Jan-Erik Lindgren, and Kurt Leander --
A common method of the research of cannabinoids from physiological resources / J. Rosenfeld --
Quantitation of [delta]⁹-tetrahydrocannabinol and its metabolites in human urine by way of chance established matching GC/MS / Donald E. eco-friendly, Fu-Chuan Chao, Kay O. Loeffler, and Saul L. Kanter --
HPLC research of [delta]⁹-tetrahydrocannabinol and metabolites in organic fluids / Seth R. Abbott, John R. Berg, Kay O. Loeffler, Saul Kanter, Leo E. Hollister, Joan Hawkins Abrams, Hugh L. Baras, and Reese T. Jones --
Radioimmunoassay of cannabinoid compounds / C.E. prepare dinner --
Antisera raised opposed to tetrahydrocannabinol within the radioimmunoassay of cannabinoids / J.D. Teale, Jacqueline M. Clough, L.J. King, V. Marks, P.L. Williams, and A.C. Moffat --
HPLC analyses of [delta]⁹-tetrahydrocannabinol and 11-nor-[delta]⁹-tetrahydrocannabinol-9-carboxylic acid in human plasma / Jimmie L. Valentine, Owen H.M. Gan, H.C. Nio, and Everett D. Thompson --
Detection and quantitation of [delta]⁹-tetrahydrocannabinol in plasma by means of dansylation and double labeling / J.M. Scherrmann, R. Bourdon, H. Hoellinger, Nguyen-Hoang Nam, and E. Fournier.

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And Tsau, T . , J. Pharm. Sci. 63, 1563 (1974). McCallum, Ν. , J. Chromatogr. 11, 509 (1973). McCallum, Ν. Κ . , Yagen, Β . , Levy, S . , and Mechoulam, R . , Experientia 31, 520 (1975). , Agurell, S . , L i n d g r e n , J. E . , Biochem. Pharmacol. 23, 163 (1974). Fetterman, R. S . , and Turner, C . , J. Pharm. Sci. 61, 147 Turner, C . , 62, 251 and 1083 (1973). Turner, C . , Hadley, K . , and Mole, M. , J. Pharm. Sci. 63, 1872 (1974). RECEIVED December 12, 1978. ; ACS Symposium Series; American Chemical Society: Washington, DC, 1979.

0 mg/kg and plasma l e v e l s o f ]L were f o l l o w e d f o r up t o 7000 m i n u t e s , no s i g n i f i c a n t d i f f e r ences were seen i n 1^ plasma l e v e l s as d e t e r m i n e d by l i q u i d s c i n t i l l a t i o n and e l e c t r o n c a p t u r e GLC a f t e r HPLC c o l l e c t i o n . The t i m e c o u r s e s f o r t h e f r a c t i o n o f t h e dose p e r ml o f plasma f o r each s t u d y was f i t by a sum o f f i v e e x p o n e n t i a l s . The f i t s were n o t s t a t i s t i c a l l y d i f f e r e n t e i t h e r among dogs o r between doses and t h e r e f o r e , no dose-dependency was c o n c l u d e d f o r t h e dose range s t u d i e d .

And H i g u c h i , W. , J. Pharm. Sci. 54, 1205 (1965). M a r t i n , A . , and Cammarata, Α . , 1969, p. 237. , " D i s s o c i a t i o n Constants o f Organic Acids in Aqueous S o l u t i o n " , I n t e r n a t i o n a l Union of Pure and A p p l i e d Chemistry, Butterworth, London, England, 1961. , N i l s s o n , I. , and A g u r e l l , S . , Biochem. Pharmacol. 19, 2579 (1970). ; ACS Symposium Series; American Chemical Society: Washington, DC, 1979. 2. GARRETT (15) (16) (17) (18) (19) (20) (21) (22) (23) (24) E T A L .

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