By Bibiana Law, I. Edward Alcamo
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Additional resources for Campylobacteriosis (Deadly Diseases and Epidemics)
Although the goal of an inflammatory response is to eliminate the foreign bodies, there is a cost to the body in which human tissue is destroyed and eliminated as well. At a localized site such as the small intestine, the area can heal if given time and rest. However, when the entire body is affected, this is a signal that the immune system is unable to take care of the infection. Immediate medical intervention is required. Along with the dilation of the blood vessels, the inflammation in enteritis results in bloody diarrhea, which exacerbates the low blood volume due to loss of fluids and blood.
Jejuni into epithelial cells and macrophages, scavengers of foreign invaders, are complex and involve a number of bacterial proteins and enzymes. Recent studies indicate that C. jejuni contains a protein called CadF in the outer membrane of its cell wall that is required for binding to intestinal epithelial cells. 11 Other proteins secreted by C. 13 Continued research will shed more light not only on how these proteins participate in successfully getting C. jejuni into the intestinal epithelial cells, but also on their degree of toxicity to the body.
Oxygen and nutrient requirements are not met, and wastes or toxins cannot be removed from the afflicted tissues. Consequently, the failure of organs such as the kidneys, brain, and lungs can lead to death. The cause of bacteremic shock is widespread dilation of the blood vessels, which results in too little blood circulating throughout the system. Bacteremic shock occurs when the bacteria and/or their products reach such high levels in the bloodstream that an inflammatory response is triggered throughout the body, not just locally at the infected site.
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