By Prof. Dr. med. Fritz Reinhard Matthias (auth.)
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Additional resources for Blood Coagulation Disorders: Hemorrhagic Diatheses and Thromboembolic Diseases
N Eng! J Med 314: 1298 Collen D (1980) On the regulations and control of fibrinolysis. Edward Kowalski memorial lecture. Thrombos Haemostas 43: 77 Goldsmith HL, Yu SSK, Marlow J (1975) Fluid mechanical stress and the platelet. Thromb Diath Haemorrh 34: 32-41 Griffin JH, Cochrane CG (1979) Recent advances in the understanding of contact activation reactions. Sem Thrombos Hemostas 5: 254 Griffin JH (1981) The contact phase of blood coagulation. In: Bloom AL, Thomas DP (eds) Haemostasis and Thrombosis.
A Factor VIII concentration of ca. 10% is sufficient to produce an approximately normal recalcification time, so this test is not suitable for diagnosing hemophilia or monitoring treatment. The "clot observation" test gives a crude and purely qualitative impression of the coagulation state. It does not require any accessories, but it should be performed only when there is no other possibility of clotting analysis. The thromboelastogram (TEG) and/or a few tests that do not require more time give more valuable results.
INTRINSIC SYSTEM surface activation XII EXTRINSIC SYSTEM tissue defect "'-(0 "'" XI ""- VIII Partial thrombo-plastin time (PTT) I V I ® Thromboplastin time (Quick) Fibrinogenl_ Fibrin Thrombin time Fig. 1. Analysis of plasmatic clotting factors: in circles, factors dependent on vitamin K 39 Tests of Plasmatic Coagulation System Function A prolonged clotting time is the characteristic feature of plasmatic coagulation disorders, namely coagulopathies in the narrower sense, with the exception of Factor VII deficiency.
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