By Philip M. Parker
In March 2001, the nationwide Institutes of overall healthiness issued the subsequent caution: ''The variety of sites delivering health-related assets grows on a daily basis. Many websites offer helpful details, whereas others can have info that's unreliable or misleading.'' moreover, due to the speedy elevate in Internet-based info, many hours might be wasted looking, picking, and printing. on the grounds that in basic terms the smallest fraction of data facing bladder melanoma is listed in se's, resembling www.google.com or others, a non-systematic method of web examine may be not just time eating, but in addition incomplete. This publication was once created for doctors, scholars, and participants of most of the people who are looking to behavior scientific examine utilizing the main complicated instruments on hand and spending the smallest amount of time doing so.
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Additional resources for Bladder Cancer - A Bibliography and Dictionary for Physicians, Patients, and Genome Researchers
Example text
The strong binding of paclitaxel to macromolecules causes it to be retained in the bladder tissue at high concentrations. Further, paclitaxel is active against human bladder cancer, and shows a higher apoptotic effect in more rapidly proliferating tumors. Paclitaxel is also more active in p53-mutated tumors compared to MMC or doxorubicin. Clearly, development of paclitaxel for intravesical application would be promising. However, as shown by our group, the cremophor micelles in the FDA-approved paclitaxel formulation entraps the drug, and significantly reduces the paclitaxel partitioning into the bladder wall, thus ruling out the use of his formulation.
Although frequently upregulated on tumor cells, complement inhibitory proteins remain largely unexplored as targets for cancer therapy due to their widespread expression. For some cancers, intracavitary delivery of a therapeutic reagent to modulate complement inhibitor function may obviate a requirement for specialized targeting strategies. It is proposed to investigate a therapeutic strategy involving intravesical (bladder) delivery of small interfering RNAs (siRNAs) to downregulate complement inhibitory proteins on bladder tumor cells, together with intravenous administration of a complement activating mAb directed against a bladder cancer-associated antigen.
Because humans are mobile, these new methods are a significant advance over approaches that ignore residential histories and instead rely only on place of residence at time of diagnosis or death. The major innovation is the creation of methods for analyzing and modeling the residential histories of cases and controls to identify geographic excesses of cancer risk, both in the study population itself as well as in relation to putative hazards such as point-source releases of carcinogens. The techniques and software to be developed in this project will provide a more concise and accurate description of clustering of cancer cases that accounts for residential history, cancer latency, time of diagnosis, and the exposure windows during which causative exposures are hypothesized to have occurred.