By Normand Voyer (auth.), F. P. Schmidtchen (eds.)

Many organic platforms nonetheless carry a number of very fascinating molecular houses that to this point can't be matched by means of manmade analogs. studying concerning the rules and methods utilized by nature could provide entry to novel nanostructures, more advantageous catalysts for the functionalization of hydrocarbon compounds or may possibly permit catalytic C-C bond formation less than environmentally benign stipulations. This quantity recapitulates the state-of-the-art in these sectors of bioorganic chemistry that, instead of mimick the traditional instance, objective to make use of the underlying ideas for worthy applications.

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5 Introduction .............................. Thiolate Coordinating Iron Porphyrins .............. P450 A n a l o g u e s with S u b s t r a t e R e c o g n i t i o n Sites . . . . E l e c t r o n Deficient M e t a l P o r p h y r i n s ............... Reductive O x y g e n Cleavage . . . . . . . . . . . 3 Final Comment . . . . . . . . . . . . . . . . 92 4 References . . . . . . . . . . . . . . . . . 93 Topics in Current Chemistry, Vol. -D. 1 Introduction The significance of cytochrome P450 catalyzed reactions has now been recognized for more than 30 years [1] as one of nature's most common and sophisticated methods to oxidize endogeneous compounds in procaryotic and eucaryotic organisms.

In addition to shedding light on important biological phenomena such as protein folding, ligand induced conformational changes, and others, these fundamental studies constitute the groundwork of the peptide based nanotechnology. Although this field of research is still in its early stage of development, it is obvious that polypeptides are ideally suited for the synthesis of novel molecular materials with interesting and useful properties. These tailor made nanostructures will surely have an important impact on many areas of research in particular drug development, molecular electronics, and material science.

40a) ~~~N~ CONH-G-E-L-A-Q-K-L-E-Q-A-L-Q-K-L-A-X 48 X---NH2 49 X=-A-A-H-Y-NH2 assembling process to create a binding site for another metal by accurately orienting the imidazole groups of three histidines near the C-terminal of 49, as depicted in Fig. 18 1-42]. They showed that Cu(II) was bound in that position and that the binding process did not influence the tertiary structure. 5 Kcal/mol. In a similar way, the group of Ghadiri [43] has succeeded in preparing a well defined four ~-helix structure 50 by forming a Ru(II) complex with four pyridine-modified peptide units 51.

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