By Frank Coke (Auth.)

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1935, X V I I I , 865. 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 RAMEL, Rev. med. , 1925, X L V , 257. H E I S T , S. SOLIS-COHEN, and M. , 1918, I I I , 261. CROWE, Charterhouse Rheumatism Clinic—Orig. Papers, 1937, I, 3. WILLIS, Amer. Rev. , 1928, X V I I , 240. BARGER and DALE, Jour, of PhysioL, X L , 128 ; Proc. Soc. Exp. Biol. , 1909, L X I , 113. ABEL and KUBOTA, Jour. Pharmacol, and Exper. Therapy, 1919, X I I I , 243. ACKERMANN, Zeits. f. , 1910, LIV, 387. BERTHELOT a n d BERTRAND, Comptes rend.

Still less can such experiences afford an explanation of the power of the bronchial muscle and its readiness for action in the guinea-pig. I am inclined to think the muscle must take part in every normal respiration, contracting during each expiration. Such an action would help to distend the alveoli at each breath and keep them patent—witness the overdistension of the lungs that takes place in asthma consequent upon the contraction of the bronchial muscle. It follows as a corollary that if this muscle contracts at each normal expiration, it will have an exaggerated action in all forms of forced expiration consequent upon exertion, laughing, or coughing.

The operation has been performed for purely surgical reasons with no t h o u g h t of benefiting the asthma, yet t h e result has shown beyond d o u b t t h e n a t u r e of the cause of the a s t h m a .

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